C-171 STING inhibitor
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H574317

CAS#: 2244881-69-2

Description: C-171 STING inhibitor is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.


Chemical Structure

img
C-171 STING inhibitor
CAS# 2244881-69-2

Theoretical Analysis

Hodoodo Cat#: H574317
Name: C-171 STING inhibitor
CAS#: 2244881-69-2
Chemical Formula: C17H20N2O4
Exact Mass: 316.14
Molecular Weight: 316.360
Elemental Analysis: C, 64.54; H, 6.37; N, 8.86; O, 20.23

Price and Availability

Size Price Availability Quantity
10mg USD 225 2 Weeks
25mg USD 400 2 Weeks
50mg USD 630 2 Weeks
100mg USD 940 2 Weeks
Bulk inquiry

Synonym: C-171, C-171 STING inhibitor

IUPAC/Chemical Name: N-(4-hexylphenyl)-5-nitro-2-furancarboxamide

InChi Key: WZVGWJZGQFSRBG-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N2O4/c1-2-3-4-5-6-13-7-9-14(10-8-13)18-17(20)15-11-12-16(23-15)19(21)22/h7-12H,2-6H2,1H3,(H,18,20)

SMILES Code: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(CCCCCC)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 316.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Haag, S.M., Gulen, M.F., Reymond, L., et al. Targeting STING with covalent small-molecule inhibitors. Nature 559(7713), 269-273 (2018).

2. Zhang, H., You, Q.-D., and Xu, X.-L. Targeting stimulator of interferon genes (STING): A medicinal chemistry perspective. J. Med. Chem. 63(8), 3785-3816 (2019).