K 4540

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H535024

CAS#: 36804-76-9

Description: K 4540 is a bioactive chemical.


Chemical Structure

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K 4540
CAS# 36804-76-9

Theoretical Analysis

Hodoodo Cat#: H535024
Name: K 4540
CAS#: 36804-76-9
Chemical Formula: C19H31ClN2O4S
Exact Mass: 418.17
Molecular Weight: 418.977
Elemental Analysis: C, 54.47; H, 7.46; Cl, 8.46; N, 6.69; O, 15.27; S, 7.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: K 4540; K4540; K-4540

IUPAC/Chemical Name: N-(1,2,3,4-Tetrahydro-8-(2-hydroxy-3-((1- methylethyl)amino)propoxy)-1,4-ethanonaphthalen-5- yl)methanesulfonamide monohydrochloride

InChi Key: PPTPTVNEMZZDAN-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H30N2O4S.ClH/c1-12(2)20-10-15(22)11-25-17-9-8-16(21-26(3,23)24)18-13-4-6-14(7-5-13)19(17)18;/h8-9,12-15,20-22H,4-7,10-11H2,1-3H3;1H

SMILES Code: CS(=O)(NC1=CC=C(OCC(O)CNC(C)C)C2=C1C3CCC2CC3)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 418.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bakhurji E, Hoaglin Cooper L. School-based fluoride varnish programs: a national survey. J Public Health Dent. 2019 Dec;79(4):279-285. doi: 10.1111/jphd.12337. Epub 2019 Sep 3. PMID: 31479531.


2: Palaiodimos L, Miles J, Kokkinidis DG, Barkolias C, Jonnalagadda AK, Papaconstantinou D, Frountzas M, Misiakos EP, Schizas D. Reversal of Novel Anticoagulants in Emergent Surgery and Trauma: A Comprehensive Review and Proposed Management Algorithm. Curr Pharm Des. 2018;24(38):4540-4553. doi: 10.2174/1381612825666181226150629. PMID: 30585542.


3: Fraser G, Cramer P, Demirkan F, Silva RS, Grosicki S, Pristupa A, Janssens A, Mayer J, Bartlett NL, Dilhuydy MS, Pylypenko H, Loscertales J, Avigdor A, Rule S, Villa D, Samoilova O, Panagiotidis P, Goy A, Pavlovsky MA, Karlsson C, Hallek M, Mahler M, Salman M, Sun S, Phelps C, Balasubramanian S, Howes A, Chanan-Khan A. Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. Leukemia. 2019 Apr;33(4):969-980. doi: 10.1038/s41375-018-0276-9. Epub 2018 Oct 12. PMID: 30315239; PMCID: PMC6484712.


4: Fensterheim BA, Young JD, Luan L, Kleinbard RR, Stothers CL, Patil NK, McAtee-Pereira AG, Guo Y, Trenary I, Hernandez A, Fults JB, Williams DL, Sherwood ER, Bohannon JK. The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism. J Immunol. 2018 Jun 1;200(11):3777-3789. doi: 10.4049/jimmunol.1800085. Epub 2018 Apr 23. PMID: 29686054; PMCID: PMC5964009.


5: Bradway M, Pfuhl G, Joakimsen R, Ribu L, Grøttland A, Årsand E. Analysing mHealth usage logs in RCTs: Explaining participants' interactions with type 2 diabetes self-management tools. PLoS One. 2018 Aug 30;13(8):e0203202. doi: 10.1371/journal.pone.0203202. PMID: 30161248; PMCID: PMC6117049.


6: Badrov MB, Park SY, Yoo JK, Hieda M, Okada Y, Jarvis SS, Stickford AS, Best SA, Nelson DB, Fu Q. Role of Corin in Blood Pressure Regulation in Normotensive and Hypertensive Pregnancy. Hypertension. 2019 Feb;73(2):432-439. doi: 10.1161/HYPERTENSIONAHA.118.12137. PMID: 30580684; PMCID: PMC6467519.


7: Courtenay AJ, McCrudden MTC, McAvoy KJ, McCarthy HO, Donnelly RF. Microneedle-Mediated Transdermal Delivery of Bevacizumab. Mol Pharm. 2018 Aug 6;15(8):3545-3556. doi: 10.1021/acs.molpharmaceut.8b00544. Epub 2018 Jul 24. PMID: 29996645.


8: Langan PS, Vandavasi VG, Weiss KL, Afonine PV, El Omari K, Duman R, Wagner A, Coates L. Anomalous X-ray diffraction studies of ion transport in K+ channels. Nat Commun. 2018 Oct 31;9(1):4540. doi: 10.1038/s41467-018-06957-w. PMID: 30382100; PMCID: PMC6208422.


9: Kim SY, Kim YJ, Jung U, Lee BH. Chemically induced Fermi level pinning effects of high-k dielectrics on graphene. Sci Rep. 2018 Feb 14;8(1):2992. doi: 10.1038/s41598-018-21055-z. PMID: 29445202; PMCID: PMC5813236.


10: Evers J, Krumm B, Axthammer QJ, Martens J, Blaha P, Steemann FX, Reith T, Mayer P, Klapötke TM. Molecular Structure of Isocyanic Acid, HNCO, the Imide of Carbon Dioxide. J Phys Chem A. 2018 Mar 29;122(12):3287-3292. doi: 10.1021/acs.jpca.8b00557. Epub 2018 Mar 20. PMID: 29513983.


11: Wang X, Dong J, Tang M, Wang X, Wang H, Zhang S. Effect of pupil dilation on biometric measurements and intraocular lens power calculations in schoolchildren. PLoS One. 2018 Sep 13;13(9):e0203677. doi: 10.1371/journal.pone.0203677. PMID: 30212545; PMCID: PMC6136745.


12: Nguyen N, Zhang S, Oluwalowo A, Park JG, Yao K, Liang R. High-Performance and Lightweight Thermal Management Devices by 3D Printing and Assembly of Continuous Carbon Nanotube Sheets. ACS Appl Mater Interfaces. 2018 Aug 15;10(32):27171-27177. doi: 10.1021/acsami.8b07556. Epub 2018 Aug 1. PMID: 30020763.


13: Rodrigues RV, Giannini M, Pascon FM, Panwar P, Brömme D, Manso AP, Carvalho RM. Effect of conditioning solutions containing ferric chloride on dentin bond strength and collagen degradation. Dent Mater. 2017 Oct;33(10):1093-1102. doi: 10.1016/j.dental.2017.07.004. Epub 2017 Aug 2. PMID: 28779890.


14: Drake-Pérez M, Delattre BMA, Boto J, Fitsiori A, Lovblad KO, Boudabbous S, Vargas MI. Normal Values of Magnetic Relaxation Parameters of Spine Components with the Synthetic MRI Sequence. AJNR Am J Neuroradiol. 2018 Apr;39(4):788-795. doi: 10.3174/ajnr.A5566. Epub 2018 Mar 1. PMID: 29496723.


15: Stockwell K, Alabdulqader E, Jackson D, Basu A, Olivier P, Pennington L. Feasibility of parent communication training with remote coaching using smartphone apps. Int J Lang Commun Disord. 2019 Mar;54(2):265-280. doi: 10.1111/1460-6984.12468. PMID: 30851010.


16: Wang L, Qiu F, Zhao Q, Zha M, Jiang Q. Superior high creep resistance of in situ nano-sized TiCx/Al-Cu-Mg composite. Sci Rep. 2017 Jul 3;7(1):4540. doi: 10.1038/s41598-017-04816-0. PMID: 28674452; PMCID: PMC5495815.


17: Littlewood DL, Quinlivan L, Graney J, Appleby L, Turnbull P, Webb RT, Kapur N. Learning from clinicians' views of good quality practice in mental healthcare services in the context of suicide prevention: a qualitative study. BMC Psychiatry. 2019 Nov 6;19(1):346. doi: 10.1186/s12888-019-2336-8. PMID: 31694598; PMCID: PMC6836656.


18: Jensen KH, Maina PJ. Cancer pathways are associated with improved long-term survival. Dan Med J. 2015 Feb;62(2):A5000. PMID: 25634507.


19: de Assis POA, Guerra GCB, Araújo DFS, de Andrade LFLI, de Araújo AA, de Araújo RF Júnior, de Carvalho TG, de Souza MFV, Borges GDSC, Lima MDS, Rolim FRL, Rodrigues RAV, Queiroga RCRDE. Intestinal anti-inflammatory activity of xique-xique (Pilosocereus gounellei A. Weber ex K. Schum. Bly. Ex Rowl) juice on acetic acid-induced colitis in rats. Food Funct. 2019 Nov 1;10(11):7275-7290. doi: 10.1039/c9fo00920e. Epub 2019 Oct 17. PMID: 31621721.


20: Garza-Veloz I, Castruita-De la Rosa C, Ortiz-Castro Y, Flores-Morales V, Castañeda-Lopez ME, Cardenas-Vargas E, Hernandez-Delgadillo GP, Ortega-Cisneros V, Luevano M, Rodriguez-Sanchez IP, Trejo-Vazquez F, Delgado-Enciso I, Cid-Baez MA, Trejo-Ortiz PM, Ramos-Del Hoyo MG, Martinez-Fierro ML. Maternal distress and the development of hypertensive disorders of pregnancy. J Obstet Gynaecol. 2017 Nov;37(8):1004-1008. doi: 10.1080/01443615.2017.1313823. Epub 2017 Jun 13. PMID: 28609179.