K00546
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H462496

CAS#: 443798-47-8

Description: K00546 is a potent CDK1 and CDK2 inhibitor and is a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor

Chemical Structure

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K00546
CAS# 443798-47-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H462496
Name: K00546
CAS#: 443798-47-8
Chemical Formula: C15H13F2N7O2S2
Exact Mass: 425.05
Molecular Weight: 425.433
Elemental Analysis: C, 42.35; H, 3.08; F, 8.93; N, 23.05; O, 7.52; S, 15.07

Price and Availability

Size Price Availability Quantity
5mg USD 500 2 Weeks
10mg USD 900 2 Weeks
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Synonym: K00546; K 00546; K-00546

IUPAC/Chemical Name: 5-amino-N-(2,6-difluorophenyl)-3-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide

InChi Key: ARIOBGGRZJITQX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)

SMILES Code: S=C(N1N=C(NC2=CC=C(S(=O)(N)=O)C=C2)N=C1N)NC3=C(F)C=CC=C3F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Pike AC, Rellos P, Niesen FH, et al. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008;27(4):704-714. doi:10.1038/emboj.2008.8

2: Fedorov O, Huber K, Eisenreich A, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011;18(1):67-76. doi:10.1016/j.chembiol.2010.11.009