H-1152 dihydrochloride
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Hodoodo CAT#: H574726

CAS#: 871543-07-6

Description: H-1152 dihydrochloride is an isoquinolinesulfonamide derivative that is a membrane-permeable inhibitor of Rho-kinase but poor inhibitor of other serine/threonine kinases.

Chemical Structure

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H-1152 dihydrochloride
CAS# 871543-07-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H574726
Name: H-1152 dihydrochloride
CAS#: 871543-07-6
Chemical Formula: C16H23Cl2N3O2S
Exact Mass: 0.00
Molecular Weight: 392.339
Elemental Analysis: C, 48.98; H, 5.91; Cl, 18.07; N, 10.71; O, 8.16; S, 8.17

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 Weeks
10mg USD 800 2 Weeks
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Synonym: H-1152 dihydrochloride; H-1152 2HCl; H1152 dihydrochloride

IUPAC/Chemical Name: 4-methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride

InChi Key: BFOPDSJOLUQULZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H

SMILES Code: CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 392.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Lie M, Grover M, Whitlon DS. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010;169(2):855-862. doi:10.1016/j.neuroscience.2010.05.020