L-002
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Hodoodo CAT#: H574767

CAS#: 321695-57-2

Description: L-002 is an inhibitor of p300 histone acyltransferase (KAT3B). L-002 also inhibits acetylation of histones and p53 and suppresses STAT3 activation. In vivo, L-002 potently suppressed tumor growth of TNBC cell line MDA-MB-468 xenografts.

Chemical Structure

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L-002
CAS# 321695-57-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H574767
Name: L-002
CAS#: 321695-57-2
Chemical Formula: C15H15NO5S
Exact Mass: 321.07
Molecular Weight: 321.347
Elemental Analysis: C, 56.07; H, 4.71; N, 4.36; O, 24.89; S, 9.98

Price and Availability

Size Price Availability Quantity
10mg USD 285 2 Weeks
50mg USD 750 2 Weeks
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Synonym: L-002, L 002, L002; p300/CBP Inhibitor VI; NSC 764414

IUPAC/Chemical Name: 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]

InChi Key: VEWFTYOFWIXCIO-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3

SMILES Code: COC1=CC=C(S(O/N=C2C=C(C)C(C(C)=C\2)=O)(=O)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 321.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Yang, H., Pinello, C.E., Luo, J., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Molecular Cancer Therapeutics 12(5), 610-620 (2013).