WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574813
CAS#: 57754-86-6 (HCl)
Description: Nisoxetine hydrochloride is a norepinephrine transporter (NET) inhibitor that inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release. It reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine and also reduces cataplexy in narcoleptic dogs.
Hodoodo Cat#: H574813
Name: Nisoxetine hydrochloride
CAS#: 57754-86-6 (HCl)
Chemical Formula: C17H22ClNO2
Exact Mass: 307.13
Molecular Weight: 307.818
Elemental Analysis: C, 66.33; H, 7.20; Cl, 11.52; N, 4.55; O, 10.40
Related CAS #: 57754-86-6 (HCl)
Synonym: Lilly 94939; Nisoxetine hydrochloride; Nisoxetine HCl; NSC 298819
IUPAC/Chemical Name: 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride
InChi Key: LCEURBZEQJZUPV-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
SMILES Code: CNCCC(C1=CC=CC=C1)OC2=C(OC)C=CC=C2.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 307.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Torres, G.E., Gainetdinov, R.R., and Caron, M.G. Plasma membrane monoamine transporters: Structure, regulation and function. Nat. Rev. Neurosci. 4(1), 13-25 (2003).
2. Tyler, T.D., and Tessel, R.E. Amphetamine’s locomotor-stimulant and noreprinephrine-releasing effects: Evidence for selective antagonism by nisoxetine. Psychopharmacology (Berl) 64(3), 291-296 (1979).
3. Tyler, T.D., and Tessel, R.E. Norepinephrine uptake inhibitors as biochemically and behaviorally selective antagonists of the locomotor stimulation induced by indirectly acting sympathomimetic aminetic amines in mice. Psychopharmacology (Berl) 69(1), 27-34 (1980).
4. Foutz, A.S., Delashaw, J.B., Jr., Guilleminault, C., et al. Monoaminergic mechanisms and experimental cataplexy. Ann. Neurol. 10(4), 369-376 (1981).