WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463084
CAS#: unknown
Description: V30-SP-8 is a novel Mycobacterium Tuberculosis VapC-Activating Stapled Peptide, successfully penetrated Mycobacterium smegmatis cell membranes and exerted bactericidal activity at a minimum inhibitory concentration that inhibited 50% of the isolates (MIC50) < 6.25 μM.
Hodoodo Cat#: H463084
Name: V30-SP-8
CAS#: unknown
Chemical Formula: C34H58N14O12
Exact Mass: 854.44
Molecular Weight: 854.924
Elemental Analysis: C, 47.77; H, 6.84; N, 22.94; O, 22.46
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Synonym: V30-SP-8; V30SP-8; V30 SP-8; V30-SP8; V30-SP 8; SLAABRHS;
IUPAC/Chemical Name: L-seryl-L-leucyl-L-alanyl-L-alanyl-L-asparaginyl-L-arginyl-L-histidyl-L-serine
InChi Key: RPNNQNSVIJFZEL-UWERRTFUSA-N
InChi Code: InChI=1S/C34H58N14O12/c1-15(2)8-21(46-28(54)19(35)12-49)30(56)43-16(3)26(52)42-17(4)27(53)45-23(10-25(36)51)32(58)44-20(6-5-7-40-34(37)38)29(55)47-22(9-18-11-39-14-41-18)31(57)48-24(13-50)33(59)60/h11,14-17,19-24,49-50H,5-10,12-13,35H2,1-4H3,(H2,36,51)(H,39,41)(H,42,52)(H,43,56)(H,44,58)(H,45,53)(H,46,54)(H,47,55)(H,48,57)(H,59,60)(H4,37,38,40)/t16-,17-,19-,20-,21-,22-,23-,24-/m0/s1
SMILES Code: O=C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 854.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kang SM, Moon H, Han SW, Kim DH, Kim BM, Lee BJ. Structure-Based De Novo Design of Mycobacterium Tuberculosis VapC-Activating Stapled Peptides. ACS Chem Biol. 2020 Sep 18;15(9):2493-2498. doi: 10.1021/acschembio.0c00492. Epub 2020 Sep 9. PMID: 32840352.