WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463099
CAS#: 77768-57-1
Description: E-0702 is an antipseudomonal cephalosporin derivative which has a broad spectrum of antibacterial activity against clinical isolates of gram-positive and gram-negative bacteria. It has significantly high in vitro antibacterial activity against gram-negative bacteria including the Pseudomonas group.
Hodoodo Cat#: H463099
Name: E 0702
CAS#: 77768-57-1
Chemical Formula: C29H21N7Na2O12S2
Exact Mass: 769.05
Molecular Weight: 769.624
Elemental Analysis: C, 45.26; H, 2.75; N, 12.74; Na, 5.97; O, 24.95; S, 8.33
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: E 0702; E0702; E-0702;
IUPAC/Chemical Name: sodium (6R,7R)-3-(((1-(carboxylatomethyl)-1H-tetrazol-5-yl)thio)methyl)-7-(2-(6,7-dihydroxy-4-oxo-4H-chromene-3-carboxamido)-2-(4-hydroxyphenyl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key: HJWFZVYGOATFNO-RPGKBGGYSA-L
InChi Code: InChI=1S/C29H23N7O12S2.2Na/c37-13-3-1-11(2-4-13)20(30-24(43)15-8-48-18-6-17(39)16(38)5-14(18)23(15)42)25(44)31-21-26(45)36-22(28(46)47)12(9-49-27(21)36)10-50-29-32-33-34-35(29)7-19(40)41;;/h1-6,8,20-21,27,37-39H,7,9-10H2,(H,30,43)(H,31,44)(H,40,41)(H,46,47);;/q;2*+1/p-2/t20?,21-,27-;;/m1../s1
SMILES Code: O=C(C(N12)=C(CSC3=NN=NN3CC([O-])=O)CS[C@]2([H])[C@H](NC(C(NC(C4=COC5=CC(O)=C(O)C=C5C4=O)=O)C6=CC=C(O)C=C6)=O)C1=O)[O-].[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 769.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Watanabe NA, Nagasu T, Katsu K, Kitoh K. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrob Agents Chemother. 1987 Apr;31(4):497-504. doi: 10.1128/aac.31.4.497. PMID: 3037997; PMCID: PMC174766.
2: Neu HC, Labthavikul P. In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):313-20. doi: 10.1128/aac.24.3.313. PMID: 6605718; PMCID: PMC185318.
3: Katsu K, Kitoh K, Inoue M, Mitsuhashi S. In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1982 Aug;22(2):181-5. doi: 10.1128/aac.22.2.181. PMID: 6100421; PMCID: PMC183706.