WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463227
CAS#: 506-48-9
Description: Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models.
Hodoodo Cat#: H463227
Name: Octacosanoic Acid
CAS#: 506-48-9
Chemical Formula: C28H56O2
Exact Mass: 424.43
Molecular Weight: 424.754
Elemental Analysis: C, 79.18; H, 13.29; O, 7.53
Synonym: Octacosanoic Acid; Montanic Acid; NSC 407311; NSC407311; NSC-407311;
IUPAC/Chemical Name: octacosanoic acid
InChi Key: UTOPWMOLSKOLTQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H56O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28(29)30/h2-27H2,1H3,(H,29,30)
SMILES Code: CCCCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 424.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ahmed SA, Rahman AA, Elsayed KNM, Abd El-Mageed HR, Mohamed HS, Ahmed SA. Cytotoxic activity, molecular docking, pharmacokinetic properties and quantum mechanics calculations of the brown macroalga Cystoseira trinodis compounds. J Biomol Struct Dyn. 2020 Jun 11:1-19. doi: 10.1080/07391102.2020.1774418. Epub ahead of print. PMID: 32462976.
2: Neipihoi, Narzary B, Saikia S, Saikia S, Tamuli KJ, Sahoo RK, Dutta D, Bordoloi M. Anticancer and antimicrobial compounds from Croton caudatus Gieseler and Eurya acuminata DC: Two edible plants used in the traditional medicine of the Kuki tribes. Nat Prod Res. 2020 Sep 16:1-5. doi: 10.1080/14786419.2020.1815737. Epub ahead of print. PMID: 32936060.
3: Tresch S, Heilmann M, Christiansen N, Looser R, Grossmann K. Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases. Phytochemistry. 2012 Apr;76:162-71. doi: 10.1016/j.phytochem.2011.12.023. Epub 2012 Jan 25. PMID: 22284369.
4: Haim D, Berríos M, Valenzuela A, Videla LA. Trace quantification of 1-octacosanol and 1-triacontanol and their main metabolites in plasma by liquid- liquid extraction coupled with gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 15;877(32):4154-8. doi: 10.1016/j.jchromb.2009.10.034. Epub 2009 Nov 11. PMID: 19931494.
5: Li Y, Yang S, Bai S. [Studies on chemical constituents from roots of Angelica polymorpha]. Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(7):854-7. Chinese. PMID: 19623980.
6: Tao ZM, Li YY, Ji P, Wang YB, Qin GW. Chemical constituents from aerial part of Curcuma wenyujin. Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2604-6. PMID: 18338597.
7: Guo QL, Yang JS, Liu JX. [Studies on the chemical constituents from Inula cappa (II)]. Zhong Yao Cai. 2007 Jan;30(1):35-7. Chinese. PMID: 17539299.
8: Zhang Y, Wolfert MA, Boons GJ. The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A. Bioorg Med Chem. 2007 Jul 15;15(14):4800-12. doi: 10.1016/j.bmc.2007.05.012. Epub 2007 May 6. PMID: 17513113; PMCID: PMC1950268.
9: Zana R. Partial phase behavior and micellar properties of tetrabutylammonium salts of fatty acids: unusual solubility in water and formation of unexpectedly small micelles. Langmuir. 2004 Jul 6;20(14):5666-8. doi: 10.1021/la040033i. PMID: 16459576.
10: Noa M, Mendoza S, Mas R, Mendoza N. Lack of protective effect of D-003, a mixture of high-molecular-weight primary acids from sugar cane wax, on liver damage induced by galactosamine in rats. J Med Food. 2005 Fall;8(3):343-7. doi: 10.1089/jmf.2005.8.343. PMID: 16176145.
11: Noa M, Mendoza S, Más R. Effect of D-003 on intimal thickening and circulating endothelial cells in rabbit cuffed carotid artery. J Med Food. 2005 Summer;8(2):237-41. doi: 10.1089/jmf.2005.8.237. PMID: 16117617.