WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463347
CAS#: 88122-99-0
Description: Octyl triazone is an approved ultraviolet-B (UV-B) chemical filter for commercial sunscreens.
Hodoodo Cat#: H463347
Name: Octyl triazone
CAS#: 88122-99-0
Chemical Formula: C48H66N6O6
Exact Mass: 822.50
Molecular Weight: 823.092
Elemental Analysis: C, 70.04; H, 8.08; N, 10.21; O, 11.66
Synonym: Octyl triazone; Ethylhexyl triazone; Uvasorb ET;
IUPAC/Chemical Name: tris(2-ethylhexyl) 4,4',4''-((1,3,5-triazine-2,4,6-triyl)tris(azanediyl))tribenzoate
InChi Key: JGUMTYWKIBJSTN-UHFFFAOYSA-N
InChi Code: InChI=1S/C48H66N6O6/c1-7-13-16-34(10-4)31-58-43(55)37-19-25-40(26-20-37)49-46-52-47(50-41-27-21-38(22-28-41)44(56)59-32-35(11-5)17-14-8-2)54-48(53-46)51-42-29-23-39(24-30-42)45(57)60-33-36(12-6)18-15-9-3/h19-30,34-36H,7-18,31-33H2,1-6H3,(H3,49,50,51,52,53,54)
SMILES Code: CCCCC(COC(c1ccc(Nc2nc(Nc3ccc(C(OCC(CCCC)CC)=O)cc3)nc(Nc4ccc(C(OCC(CCCC)CC)=O)cc4)n2)cc1)=O)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 823.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Scalia S, Battaglioli S, Bianchi A. In vivo Human Skin Penetration of the UV Filter Ethylhexyl Triazone: Effect of Lipid Microparticle Encapsulation. Skin Pharmacol Physiol. 2019;32(1):22-31. doi: 10.1159/000493761. Epub 2018 Oct 31. PMID: 30380536.
2: Baker LA, Clark SL, Habershon S, Stavros VG. Ultrafast Transient Absorption Spectroscopy of the Sunscreen Constituent Ethylhexyl Triazone. J Phys Chem Lett. 2017 May 18;8(10):2113-2118. doi: 10.1021/acs.jpclett.7b00633. Epub 2017 Apr 28. PMID: 28437110.
3: Hojerová J, Peráčková Z, Beránková M. Margin of safety for two UV filters estimated by in vitro permeation studies mimicking consumer habits: Effects of skin shaving and sunscreen reapplication. Food Chem Toxicol. 2017 May;103:66-78. doi: 10.1016/j.fct.2017.02.013. Epub 2017 Feb 16. PMID: 28216167.
4: Freitas JV, Lopes NP, Gaspar LR. Photostability evaluation of five UV- filters, trans-resveratrol and beta-carotene in sunscreens. Eur J Pharm Sci. 2015 Oct 12;78:79-89. doi: 10.1016/j.ejps.2015.07.004. Epub 2015 Jul 6. PMID: 26159738.
5: Couteau C, Chauvet C, Paparis E, Coiffard L. UV filters, ingredients with a recognized anti-inflammatory effect. PLoS One. 2012;7(12):e46187. doi: 10.1371/journal.pone.0046187. Epub 2012 Dec 20. PMID: 23284607; PMCID: PMC3527392.
6: Sobanska AW, Pyzowski J. Quantification of sunscreen ethylhexyl triazone in topical skin-care products by normal-phase TLC/densitometry. ScientificWorldJournal. 2012;2012:807516. doi: 10.1100/2012/807516. Epub 2012 May 2. PMID: 22629203; PMCID: PMC3353564.
7: Kim D, Kim S, Kim SA, Choi M, Kwon KJ, Kim M, Kim DS, Kim SH, Choi BK. Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high- performance liquid chromatography. J Cosmet Sci. 2012 Mar-Apr;63(2):103-17. PMID: 22591562.
8: Lhiaubet-Vallet V, Marin M, Jimenez O, Gorchs O, Trullas C, Miranda MA. Filter-filter interactions. Photostabilization, triplet quenching and reactivity with singlet oxygen. Photochem Photobiol Sci. 2010 Apr;9(4):552-8. doi: 10.1039/b9pp00158a. PMID: 20354650.
9: Bryden AM, Moseley H, Ibbotson SH, Chowdhury MM, Beck MH, Bourke J, English J, Farr P, Foulds IS, Gawkrodger DJ, George S, Orton DI, Shaw S, McFadden J, Norris P, Podmore P, Powell S, Rhodes LE, Sansom J, Wilkinson M, van Weelden H, Ferguson J. Photopatch testing of 1155 patients: results of the U.K. multicentre photopatch study group. Br J Dermatol. 2006 Oct;155(4):737-47. doi: 10.1111/j.1365-2133.2006.07458.x. PMID: 16965423.
10: Kupper T, Plagellat C, Brändli RC, de Alencastro LF, Grandjean D, Tarradellas J. Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment. Water Res. 2006 Aug;40(14):2603-12. doi: 10.1016/j.watres.2006.04.012. Epub 2006 Jun 23. PMID: 16797670.
11: Plagellat C, Kupper T, Furrer R, de Alencastro LF, Grandjean D, Tarradellas J. Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland. Chemosphere. 2006 Feb;62(6):915-25. doi: 10.1016/j.chemosphere.2005.05.024. Epub 2005 Jul 5. PMID: 15996716.
12: Sommer S, Wilkinson SM, English JS, Ferguson J. Photoallergic contact dermatitis from the sunscreen octyl triazone. Contact Dermatitis. 2002 May;46(5):304-5. doi: 10.1034/j.1600-0536.2002.460514.x. PMID: 12084089.
13: Potard G, Laugel C, Schaefer H, Marty JP. The stripping technique: in vitro absorption and penetration of five UV filters on excised fresh human skin. Skin Pharmacol Appl Skin Physiol. 2000 Nov-Dec;13(6):336-44. doi: 10.1159/000029941. PMID: 11096375.
14: Potard G, Laugel C, Baillet A, Schaefer H, Marty JP. Quantitative HPLC analysis of sunscreens and caffeine during in vitro percutaneous penetration studies. Int J Pharm. 1999 Nov 5;189(2):249-60. doi: 10.1016/s0378-5173(99)00258-6. PMID: 10536254.
15: Degwert J, Pape W, Hoppe U. In vitro analysis of immunoprotective effects of topical sunscreens. Toxicol In Vitro. 1994 Aug;8(4):747-9. doi: 10.1016/0887-2333(94)90058-2. PMID: 20693002.
16: Et MH, Masse MO. Dosage de l'octyl triazone dans les produits cosmétiques solaires. Int J Cosmet Sci. 1992 Jun;14(3):113-9. doi: 10.1111/j.1467-2494.1992.tb00046.x. PMID: 19272095.
