C48/80
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H463438

CAS#: 4091-50-3

Description: C48/80 is an inducer of mast cell degranulation.

Chemical Structure

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C48/80
CAS# 4091-50-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H463438
Name: C48/80
CAS#: 4091-50-3
Chemical Formula: C10H15NO
Exact Mass: 165.12
Molecular Weight: 165.236
Elemental Analysis: C, 72.69; H, 9.15; N, 8.48; O, 9.68

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
2g USD 450 2 Weeks
5g USD 950 2 Weeks
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Synonym: C48/80; C4880; C48 80; C48-80; Compound 48/80; BW-4880; BW4880; BW 4880;

IUPAC/Chemical Name: 2-(4-methoxyphenyl)-N-methylethan-1-amine

InChi Key: JCMWSVNNSPUNER-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H15NO/c1-11-8-7-9-3-5-10(12-2)6-4-9/h3-6,11H,7-8H2,1-2H3

SMILES Code: CNCCC1=CC=C(OC)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 165.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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4: Dondalska A, Rönnberg E, Ma H, Pålsson SA, Magnusdottir E, Gao T, Adam L, Lerner EA, Nilsson G, Lagerström M, Spetz AL. Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide. Front Immunol. 2020 Sep 30;11:559589. doi: 10.3389/fimmu.2020.559589. PMID: 33101278; PMCID: PMC7554336.

5: Babina M, Wang Z, Roy S, Guhl S, Franke K, Artuc M, Ali H, Zuberbier T. MRGPRX2 is the codeine receptor of human skin mast cells: desensitization via β-arrestin and lack of correlation with the FcεRI pathway. J Invest Dermatol. 2020 Oct 12:S0022-202X(20)32150-3. doi: 10.1016/j.jid.2020.09.017. Epub ahead of print. PMID: 33058860.

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7: Cao J, Wang Y, Hu S, Ding Y, Jia Q, Zhu J, An H. Kaempferol ameliorates secretagogue-induced pseudo-allergic reactions via inhibiting intracellular calcium fluctuation. J Pharm Pharmacol. 2020 Sep;72(9):1221-1231. doi: 10.1111/jphp.13312. Epub 2020 Jun 18. PMID: 32557699.

8: Xiong W, Yao M, Zhou R, Qu Y, Yang Y, Wang Z, Song N, Chen H, Qian J. Oxytocin ameliorates ischemia/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart. Biomed Pharmacother. 2020 Aug;128:110358. doi: 10.1016/j.biopha.2020.110358. Epub 2020 Jun 8. PMID: 32526456.

9: Tabat MW, Marques TM, Markgren M, Löfvendahl L, Brummer RJ, Wall R. Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues. Biomolecules. 2020 May 14;10(5):766. doi: 10.3390/biom10050766. PMID: 32422994; PMCID: PMC7277647.

10: Liao H, Peng X, Ge Y, Liang Y, Yin Y, Li J, Lin L, Wang J, Li Y, Li L. Novel reactivation and degranulation of mast cells. Biomed Pharmacother. 2020 Jul;127:110157. doi: 10.1016/j.biopha.2020.110157. Epub 2020 May 6. PMID: 32388238.

11: Nian JB, Zeng M, Zheng J, Zeng LY, Fu Z, Huang QJ, Wei X. Epithelial cells expressed IL-33 to promote degranulation of mast cells through inhibition on ST2/PI3K/mTOR-mediated autophagy in allergic rhinitis. Cell Cycle. 2020 May;19(10):1132-1142. doi: 10.1080/15384101.2020.1749402. Epub 2020 Apr 16. PMID: 32298206; PMCID: PMC7217365.

12: Albuquerque AAS, Ferreira LG, Carvalho MTM, Capellini VK, Evora PRB, Celotto AC. Effects of NO/cGMP inhibitors in a rat model of anaphylactoid shock. Braz J Med Biol Res. 2020 Mar 2;53(3):e8853. doi: 10.1590/1414-431X20198853. PMID: 32130289; PMCID: PMC7057939.

13: Kühn H, Kappes L, Wolf K, Gebhardt L, Neurath MF, Reeh P, Fischer MJM, Kremer AE. Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling. Sci Rep. 2020 Feb 11;10(1):2326. doi: 10.1038/s41598-020-59092-2. PMID: 32047194; PMCID: PMC7012836.

14: Wang J, Zhang Y, Li C, Ding Y, Hu S, An H. Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue. Phytomedicine. 2020 Mar;68:153149. doi: 10.1016/j.phymed.2019.153149. Epub 2019 Dec 16. PMID: 32032836.

15: Springer JM, Raveendran VV, Zhang M, Funk R, Smith DD, Maz M, Dileepan KN. Mast Cell Degranulation Decreases Lipopolysaccharide-Induced Aortic Gene Expression and Systemic Levels of Interleukin-6 In Vivo. Mediators Inflamm. 2019 Oct 24;2019:3856360. doi: 10.1155/2019/3856360. PMID: 31780858; PMCID: PMC6855011.

16: Lu ZF, Min J, Wu XC, Dong BH, Ye JM, Liu XB, Zhang L, Guo B, Gao ZJ. Andrographolide inhibits secretagogue-induced pseudo-allergic reaction. J Asian Nat Prod Res. 2020 Nov;22(11):1065-1077. doi: 10.1080/10286020.2019.1681408. Epub 2019 Nov 25. PMID: 31762317.

17: Wang J, Zhang Y, Wang J, Liu R, Zhang G, Dong K, Zhang T. Paeoniflorin inhibits MRGPRX2-mediated pseudo-allergic reaction via calcium signaling pathway. Phytother Res. 2020 Feb;34(2):401-408. doi: 10.1002/ptr.6531. Epub 2019 Oct 31. PMID: 31667930.

18: Chen YL, Cai B, Zhang W, Xie ZQ, Huang W, Pan L, Lu M. [Study on safflower yellow for injection based on cell degranulation and acute anaphylactoid model]. Zhongguo Zhong Yao Za Zhi. 2019 Sep;44(17):3792-3797. Chinese. doi: 10.19540/j.cnki.cjcmm.20190522.401. PMID: 31602955.

19: Xie JJ, Zhang LB, Yi JJ, Kang LJ, Zhao L. [Establishment of new evaluation standards for systemic anaphylactoid reactions using mouse model]. Zhongguo Zhong Yao Za Zhi. 2019 Sep;44(17):3763-3772. Chinese. doi: 10.19540/j.cnki.cjcmm.20190422.401. PMID: 31602951.

20: Huang B, Huang S, Chen X, Liu XB, Wu Q, Wang Y, Li X, Li K, Gao H, Cen S, Lin R, Liu Z, Jin X. Activation of Mast Cells Promote Plasmodium berghei ANKA Infection in Murine Model. Front Cell Infect Microbiol. 2019 Sep 10;9:322. doi: 10.3389/fcimb.2019.00322. PMID: 31552201; PMCID: PMC6747038.