WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H575092
CAS#: 329-63-5 (HCl)
Description: Racepinephrine hydrochloride is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors. Through these receptors, (±)-epinephrine may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression. Receptor-mediated actions of (±)-epinephrine are also relevant to blocking anaphylaxis, reversing cardiac arrest, and reducing bleeding in clinical trials.
Hodoodo Cat#: H575092
Name: Racepinephrine hydrochloride
CAS#: 329-63-5 (HCl)
Chemical Formula: C9H14ClNO3
Exact Mass: 219.07
Molecular Weight: 219.660
Elemental Analysis: C, 49.21; H, 6.42; Cl, 16.14; N, 6.38; O, 21.85
Related CAS #: 329-65-7 (free base) 329-63-5 (HCl)
Synonym: (±)-Adrenaline; DL-Adrenaline; DL-Epinephrine; Racepinephrine hydrochloride; Racepinephrine HCl;
IUPAC/Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol, monohydrochloride
InChi Key: ATADHKWKHYVBTJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
SMILES Code: OC1=C(O)C=CC(C(O)CNC)=C1.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 219.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Rothman, R.B., Vu, N., Partilla, J.S., et al. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J. Pharmacol. Exp. Ther. 307(1), 138-145 (2003).
2. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch. Pharmacol. 369(2), 151-159 (2004).
3. Ahles, A., and Englehardt, S. Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in disease. Pharmacol. Rev. 66(3), 598-637 (2014).
4. Werner-Busse, A., Zuberbier, T., and Worm, M. The allergic emergency--management of severe allergic reactions. J.Dtsch.Dermatol.Ges. 12(5), 379-387 (2014).
5. Chen, S.q. Advances in clinical studies of cardiopulmonary resuscitation. World J.Emerg.Med. 6(2), 85-93 (2015).
6. Wilkins, T., Khan, N., Nabh, A., et al. Diagnosis and management of upper gastrointestinal bleeding. American Family Physician 85(5), 469-476 (2012).
