WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412531
CAS#: 234096-34-5 (free base)
Description: Cefovecin (free base) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs. It is marketed by Zoetis under the trade name Convenia. It is used to treat skin infections caused by Pasteurella multocida in cats, and Staphylococcus intermedius and Streptococcus canis in dogs.
Hodoodo Cat#: H412531
Name: Cefovecin (free base)
CAS#: 234096-34-5 (free base)
Chemical Formula: C17H19N5O6S2
Exact Mass: 453.08
Molecular Weight: 453.490
Elemental Analysis: C, 45.03; H, 4.22; N, 15.44; O, 21.17; S, 14.14
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 234096-34-5 (free base) 141195-77-9 (sodium)
Synonym: Cefovecin (free base); UNII-0D1OL46ZIE
IUPAC/Chemical Name: (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-3-((S)-tetrahydrofuran-2-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChi Key: ZJGQFXVQDVCVOK-QFKLAVHZSA-N
InChi Code: InChI=1S/C17H19N5O6S2/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26)/b21-10-/t9-,11+,15+/m0/s1
SMILES Code: O=C(C(N12)=C([C@H]3OCCC3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 453.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Seeley KE, Wolf KN, Bishop MA, Turnquist M, KuKanich B. Pharmacokinetics of long-acting cefovecin in copper rockfish (Sebastes caurinus). Am J Vet Res. 2016 Mar;77(3):260-4. doi: 10.2460/ajvr.77.3.260. PMID: 26919596.
2: Lawrence M, Kukanich K, Kukanich B, Heinrich E, Coetzee JF, Grauer G, Narayanan S. Effect of cefovecin on the fecal flora of healthy dogs. Vet J. 2013 Oct;198(1):259-66. doi: 10.1016/j.tvjl.2013.04.010. Epub 2013 May 20. PMID: 23702279.
3: Cushing AC, Ramsay EC, Steeil J, Cox S. PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS ( PANTHERA TIGRIS). J Zoo Wildl Med. 2017 Dec;48(4):1188-1192. doi: 10.1638/2017-0083.1. PMID: 29297795.
4: Nardini G, Barbarossa A, Dall'Occo A, Di Girolamo N, Cagnardi P, Magnone W, Bielli M, Roncada P, Zaghini A. Pharmacokinetics of cefovecin sodium after subcutaneous administration to Hermann's tortoises (Testudo hermanni). Am J Vet Res. 2014 Oct;75(10):918-23. doi: 10.2460/ajvr.75.10.918. PMID: 25255182.
5: Sanders KL, Bas E, Cox SK, Rothen DE. Pharmacokinetics of Single-bolus Subcutaneous Cefovecin in C57BL/6 Mice. J Am Assoc Lab Anim Sci. 2017 Sep 1;56(5):558-561. PMID: 28903828; PMCID: PMC5605181.
6: Stegemann MR, Sherington J, Blanchflower S. Pharmacokinetics and pharmacodynamics of cefovecin in dogs. J Vet Pharmacol Ther. 2006 Dec;29(6):501-11. doi: 10.1111/j.1365-2885.2006.00801.x. PMID: 17083454.
7: Gharibi S, Vogelnest L, Govendir M. In vitro binding of cefovecin to plasma proteins in Australian marsupials and plasma concentrations of cefovecin following single subcutaneous administration to koalas (Phascolarctos cinereus). Aust Vet J. 2019 Mar;97(3):75-80. doi: 10.1111/avj.12785. PMID: 30809814.
8: Passmore CA, Sherington J, Stegemann MR. Efficacy and safety of cefovecin for the treatment of urinary tract infections in cats. J Small Anim Pract. 2008 Jun;49(6):295-301. doi: 10.1111/j.1748-5827.2008.00545.x. Epub 2008 Apr 14. PMID: 18422501.
9: Bakker J, Thuesen LR, Braskamp G, Skaanild MT, Ouwerling B, Langermans JA, Bertelsen MF. Single subcutaneous dosing of cefovecin in rhesus monkeys (Macaca mulatta): a pharmacokinetic study. J Vet Pharmacol Ther. 2011 Oct;34(5):464-8. doi: 10.1111/j.1365-2885.2010.01265.x. Epub 2011 Feb 17. PMID: 21323930.
10: Flaminio KP, Christensen JM, Alshahrani SM, Mohammed SM. Pharmacokinetics after subcutaneous administration of a single dose of cefovecin sodium in African lions (Panthera leo). Am J Vet Res. 2019 Mar;80(3):230-234. doi: 10.2460/ajvr.80.3.230. PMID: 30801211.
