WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H575279
CAS#: 151272-15-0
Description: F-327 is an oxytocin antagonist.
Hodoodo Cat#: H575279
Name: F-327
CAS#: 151272-15-0
Chemical Formula: C42H67N11O11S
Exact Mass: 933.47
Molecular Weight: 934.120
Elemental Analysis: C, 54.00; H, 7.23; N, 16.49; O, 18.84; S, 3.43
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Synonym: F-327; F327; F 327
IUPAC/Chemical Name: (2S)-1-((4S,7S,10S,13S,16R,19R)-19-amino-7-(2-amino-2-oxoethyl)-13-(sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((S)-1,5-diamino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
InChi Key: QEFQIGQJUGMXCA-NZVKYZORSA-N
InChi Code: InChI=1S/C42H67N11O11S/c1-5-22(3)33-40(61)52-34(23(4)54)41(62)50-30(20-32(45)55)37(58)48-28(42(63)53-17-8-10-31(53)39(60)47-27(35(46)56)9-7-16-43)15-18-65-21-26(44)36(57)49-29(38(59)51-33)19-24-11-13-25(14-12-24)64-6-2/h11-14,22-23,26-31,33-34,54H,5-10,15-21,43-44H2,1-4H3,(H2,45,55)(H2,46,56)(H,47,60)(H,48,58)(H,49,57)(H,50,62)(H,51,59)(H,52,61)/t22?,23-,26+,27+,28+,29-,30+,31+,33+,34+/m1/s1
SMILES Code: CCOc1ccc(C[C@H]2NC(=O)[C@@H](N)CSCC[C@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)C(C)CC)[C@@H](C)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 934.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Thornton S, Gillespie JI, Anson LC, Greenwell JR, Melin P, Dunlop W. The effect of the oxytocin antagonists, CAP 476 and F327, on calcium mobilisation in single cultured human myometrial cells. Br J Obstet Gynaecol. 1993 Jun;100(6):581-6. doi: 10.1111/j.1471-0528.1993.tb15314.x. PMID: 8392862.