WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463676
CAS#: 149007-54-5 (hydrochloride)
Description: WAY-100135 hydrochloride is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A. It is selective for 5-HT1A over 5-HT1B, 5-HT1C, and 5-HT2 receptors, as well as dopamine D1 and D2, and α1-, α2-, and β-adrenergic receptors. WAY-100135 hydrochloride increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.
Hodoodo Cat#: H463676
Name: WAY-100135 hydrochloride
CAS#: 149007-54-5 (hydrochloride)
Chemical Formula: C24H35Cl2N3O2
Exact Mass: 467.21
Molecular Weight: 468.463
Elemental Analysis: C, 61.53; H, 7.53; Cl, 15.13; N, 8.97; O, 6.83
Related CAS #: 149007-54-5 (hydrochloride) 133025-23-7 (free)
Synonym: WAY-100135 hydrochloride; WAY 100135 hydrochloride; WAY100135 hydrochloride; (S)-WAY-100135 hydrochloride; (S)-WAY100135 hydrochloride; (S)-WAY 100135 hydrochloride;
IUPAC/Chemical Name: (S)-N-(tert-butyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropanamide dihydrochloride
InChi Key: VJGZNBYDSDEOED-FAVHNTAZSA-N
InChi Code: InChI=1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H/t20-;;/m1../s1
SMILES Code: COC1=C(C=CC=C1)N2CCN(C[C@@H](C(NC(C)(C)C)=O)C3=CC=CC=C3)CC2.Cl.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 468.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Han L, Wu KL, Kwan PY, Chua OW, Shum DK, Chan YS. 5-HT1A receptor- mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. J Physiol. 2020 Oct 2. doi: 10.1113/JP280610. Epub ahead of print. PMID: 33006159.
2: Yaman B, Bal R. Pindolol potentiates the antidepressant effect of venlafaxine by inhibiting 5-HT1A receptor in DRN neurons of mice. Int J Neurosci. 2020 Jul 23:1-8. doi: 10.1080/00207454.2020.1797723. Epub ahead of print. PMID: 32677492.
3: Wang B, Sun S, Liu M, Chen H, Liu N, Wu Z, Wu G, Dai Z. Dietary L-Tryptophan Regulates Colonic Serotonin Homeostasis in Mice with Dextran Sodium Sulfate- Induced Colitis. J Nutr. 2020 Jul 1;150(7):1966-1976. doi: 10.1093/jn/nxaa129. PMID: 32386234.
4: Cinelli E, Mutolo D, Iovino L, Pantaleo T, Bongianni F. Key role of 5-HT1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys. Eur J Neurosci. 2020 Oct;52(8):3903-3917. doi: 10.1111/ejn.14769. Epub 2020 May 26. PMID: 32378271.
5: Zamberlam CR, Tilger MAS, Moraes L, Cerutti JM, Cerutti SM. Ginkgo biloba treatments reverse the impairment of conditioned suppression acquisition induced by GluN2B-NMDA and 5-HT1A receptor blockade: Modulatory effects of the circuitry of the dorsal hippocampal formation. Physiol Behav. 2019 Oct 1;209:112534. doi: 10.1016/j.physbeh.2019.04.023. Epub 2019 May 6. PMID: 31071338.
6: Mesbahzadeh B, Moradi-Kor N, Abbasi-Maleki S. Zinc enhances the expression of morphine-induced conditioned place preference through dopaminergic and serotonergic systems. Biomol Concepts. 2019 Apr 3;10(1):51-61. doi: 10.1515/bmc-2019-0006. PMID: 30956225.
7: Jesus CHA, Redivo DDB, Gasparin AT, Sotomaior BB, de Carvalho MC, Genaro K, Zuardi AW, Hallak JEC, Crippa JA, Zanoveli JM, da Cunha JM. Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors. Brain Res. 2019 Jul 15;1715:156-164. doi: 10.1016/j.brainres.2019.03.014. Epub 2019 Mar 18. PMID: 30898678.
8: Sobrido-Cameán D, Robledo D, Sánchez L, Rodicio MC, Barreiro-Iglesias A. Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys. Dis Model Mech. 2019 Feb 20;12(2):dmm037085. doi: 10.1242/dmm.037085. PMID: 30709851; PMCID: PMC6398502.
9: Abbasi-Maleki S, Kadkhoda Z, Taghizad-Farid R. The antidepressant-like effects of Origanum majorana essential oil on mice through monoaminergic modulation using the forced swimming test. J Tradit Complement Med. 2019 Jan 14;10(4):327-335. doi: 10.1016/j.jtcme.2019.01.003. PMID: 32695649; PMCID: PMC7365779.
10: Iovino L, Mutolo D, Cinelli E, Contini M, Pantaleo T, Bongianni F. Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit. Brain Res. 2019 Feb 1;1704:26-39. doi: 10.1016/j.brainres.2018.09.020. Epub 2018 Sep 19. PMID: 30244021.
11: Li YH, Xiang K, Xu X, Zhao X, Li Y, Zheng L, Wang J. Co-activation of both 5-HT1A and 5-HT7 receptors induced attenuation of glutamatergic synaptic transmission in the rat visual cortex. Neurosci Lett. 2018 Nov 1;686:122-126. doi: 10.1016/j.neulet.2018.09.013. Epub 2018 Sep 8. PMID: 30205142.
12: Kunisawa N, Iha HA, Nomura Y, Onishi M, Matsubara N, Shimizu S, Ohno Y. Serotonergic modulation of nicotine-induced kinetic tremor in mice. J Pharmacol Sci. 2017 Jun;134(2):131-138. doi: 10.1016/j.jphs.2017.06.001. Epub 2017 Jun 9. PMID: 28647281.
13: Li YH, Han L, Wu KLK, Chan YS. Activation of 5-HT7 receptors reverses NMDA-R-dependent LTD by activating PKA in medial vestibular neurons. Neuropharmacology. 2017 Sep 1;123:242-248. doi: 10.1016/j.neuropharm.2017.05.005. Epub 2017 May 5. PMID: 28483393.
14: Dremencov E, Csatlósová K, Durišová B, Moravcíková L, Lacinová L, Ježová D. Effect of Physical Exercise and Acute Escitalopram on the Excitability of Brain Monoamine Neurons: In Vivo Electrophysiological Study in Rats. Int J Neuropsychopharmacol. 2017 Jul 1;20(7):585-592. doi: 10.1093/ijnp/pyx024. Erratum in: Int J Neuropsychopharmacol. 2017 Nov 1;21(1):95. PMID: 28430979; PMCID: PMC5492809.
15: Fischer L, Lavoranti MI, de Oliveira Borges M, Miksza AF, Sardi NF, Martynhak BJ, Tambeli CH, Parada CA. TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception. Inflamm Res. 2017 Apr;66(4):311-322. doi: 10.1007/s00011-016-1015-1. Epub 2016 Nov 30. PMID: 27904941.
16: Xiang K, Zhao X, Li Y, Zheng L, Wang J, Li YH. Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex. Curr Neurovasc Res. 2016;13(4):321-328. doi: 10.2174/1567202613666160823164136. PMID: 27558200.
17: Zádori ZS, Fehér Á, Tóth VE, Al-Khrasani M, Köles L, Sipos S, Del Bello F, Pigini M, Gyires K. Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility. Dig Dis Sci. 2016 Jun;61(6):1512-23. doi: 10.1007/s10620-015-4026-9. Epub 2016 Feb 10. PMID: 26860509.
18: García-Barba C, Medina-Ceja L. Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid. Brain Res Bull. 2016 Mar;121:59-67. doi: 10.1016/j.brainresbull.2016.01.003. Epub 2016 Jan 6. PMID: 26772625.
19: Kreiner G, Roman A, Zelek-Molik A, Kowalska M, Nalepa I. A lack of α1A-adrenergic receptor-mediated antidepressant-like effects of S-(+)-niguldipine and B8805-033 in the forced swim test. Behav Pharmacol. 2016 Jun;27(4):397-401. doi: 10.1097/FBP.0000000000000204. PMID: 26588212.
20: Kazmierska P, Konopacki J. Development of theta rhythm in hippocampal formation slices perfused with 5-HT1A antagonist, (S)WAY 100135. Brain Res. 2015 Nov 2;1625:142-50. doi: 10.1016/j.brainres.2015.08.041. Epub 2015 Sep 7. PMID: 26358147.
