WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412833
CAS#: 525-61-1
Description: Quinocide is a biochemical for proteomics research
Hodoodo Cat#: H412833
Name: Quinocide
CAS#: 525-61-1
Chemical Formula: C15H21N3O
Exact Mass: 259.17
Molecular Weight: 259.350
Elemental Analysis: C, 69.47; H, 8.16; N, 16.20; O, 6.17
Synonym: Quinocide; NSC50986; NSC-50986; NSC 50986
IUPAC/Chemical Name: 1,4-Pentanediamine, N1-(6-methoxy-8-quinolinyl)- (9CI)
InChi Key: NBAFIBBHADOTMU-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H21N3O/c1-11(16)5-3-7-17-14-10-13(19-2)9-12-6-4-8-18-15(12)14/h4,6,8-11,17H,3,5,7,16H2,1-2H3
SMILES Code: CC(N)CCCNC1=C2N=CC=CC2=CC(OC)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 259.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Elbashir AA, Saad B, Ali AS, Saleh MI, Aboul-Enein HY. Determination of quinocide as impurity in primaquine tablets by capillary zone electrophoresis. Biomed Chromatogr. 2009 May;23(5):464-71. doi: 10.1002/bmc.1137. PMID: 19016231.
2: Brondz I, Fialkov AB, Amirav A. Analysis of quinocide in unprocessed primaquine diphosphate and primaquine diphosphate tablets using gas chromatography-mass spectrometry with supersonic molecular beams. J Chromatogr A. 2009 Jan 30;1216(5):824-9. doi: 10.1016/j.chroma.2008.11.043. Epub 2008 Nov 21. Erratum in: J Chromatogr A. 2009 Mar 20;1216(12):2609-10. PMID: 19108846.
3: LYSENKO AY. Use of quinocide in treatment and prophylaxis of vivax malaria. Bull World Health Organ. 1960;22(6):641-62. PMID: 14419205; PMCID: PMC2555349.
4: MARUASHVILI GM, BAKRADZE TL, KANDELAKI NS, VEKUA MA, KARDAVA AG. Lechenie bol'nykh maliariei khinotsidom [Quinocide therapy of malaria]. Med Parazitol (Mosk). 1958 Jul-Aug;27(4):406-8. Russian. PMID: 13589459.
5: Brondz I, Ekeberg D, Bell DS, Annino AR, Hustad JA, Svendsen R, Vlachos V, Oakley P, Langley GJ, Mohini T, Amaury CG, Mikhalitsyn F. Nature of the main contaminant in the drug primaquine diphosphate: SFC and SFC-MS methods of analysis. J Pharm Biomed Anal. 2007 Feb 19;43(3):937-44. doi: 10.1016/j.jpba.2006.09.017. Epub 2006 Oct 31. PMID: 17079107.
6: Elbashir AA, Saad B, Ali AS, Saleh MI, Aboul-Enein HY. Enantioselective analysis of primaquine and its impurity quinocide by capillary electrophoresis. Biomed Chromatogr. 2009 Mar;23(3):295-301. doi: 10.1002/bmc.1113. PMID: 18816453.
7: Elbashir AA, Suliman FE, Saad B, Aboul-Enein HY. Capillary electrophoretic separation and computational modeling of inclusion complexes of beta- cyclodextrin and 18-crown-6 ether with primaquine and quinocide. Biomed Chromatogr. 2010 Apr;24(4):393-8. doi: 10.1002/bmc.1304. PMID: 19650150.
8: Brondz I, Mantzilas D, Klein U, Ekeberg D, Hvattum E, Lebedeva MN, Mikhailitsyn FS, Souleimanov GD, Røe J. Nature of the main contaminant in the anti malaria drug primaquine diphosphate: a qualitative isomer analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Feb 5;800(1-2):211-23. doi: 10.1016/j.jchromb.2003.09.042. PMID: 14698257.
9: Németh K, Tárkányi G, Varga E, Imre T, Mizsei R, Iványi R, Visy J, Szemán J, Jicsinszky L, Szente L, Simonyi M. Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins. J Pharm Biomed Anal. 2011 Feb 20;54(3):475-81. doi: 10.1016/j.jpba.2010.09.020. Epub 2010 Sep 19. PMID: 20943339.
10: TIBURSKAIA NA, GLADKIKH VF, GRINBERG EM. [Data on the studies of the organ of vision following administration of quinocide]. Med Parazitol (Mosk). 1959 Jul-Aug;28:454-6. Russian. PMID: 13838302.
