WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463825
CAS#: unknown
Description: F0045 is a novel influenza A hemagglutinin (HA) fusion inhibitor, preventing HA from transitioning to the post-fusion state at pH 5.0.
Hodoodo Cat#: H463825
Name: F0045
CAS#: unknown
Chemical Formula: C17H15Cl2NO2
Exact Mass: 335.05
Molecular Weight: 336.212
Elemental Analysis: C, 60.73; H, 4.50; Cl, 21.09; N, 4.17; O, 9.52
This product is not in stock, which may be available by custom synthesis.
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Synonym: F0045; F 0045; F-0045;
IUPAC/Chemical Name: (R)-(2,4-dichlorophenyl)(2-phenylmorpholino)methanone
InChi Key: GMCUGOLAHOHCSS-INIZCTEOSA-N
InChi Code: InChI=1S/C17H15Cl2NO2/c18-13-6-7-14(15(19)10-13)17(21)20-8-9-22-16(11-20)12-4-2-1-3-5-12/h1-7,10,16H,8-9,11H2/t16-/m0/s1
SMILES Code: O=C(C1=CC=C(Cl)C=C1Cl)N2C[C@@H](C3=CC=CC=C3)OCC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 336.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yao Y, Kadam RU, Lee CD, Woehl JL, Wu NC, Zhu X, Kitamura S, Wilson IA, Wolan DW. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18431-18438. doi: 10.1073/pnas.2006893117. Epub 2020 Jul 20. PMID: 32690700; PMCID: PMC7414093.