WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463904
CAS#: 1973494-16-4 (R-isomer)
Description: BA-1049 is a selective ROCK2 inhibitor.
Hodoodo Cat#: H463904
Name: BA-1049
CAS#: 1973494-16-4 (R-isomer)
Chemical Formula: C16H21N3O2S
Exact Mass: 319.14
Molecular Weight: 319.423
Elemental Analysis: C, 60.16; H, 6.63; N, 13.16; O, 10.02; S, 10.04
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1973494-16-4 (R-isomer) 2146097-17-6 (S-isomer)
Synonym: BA-1049; BA1049; BA 1049;
IUPAC/Chemical Name: (R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine
InChi Key: MGLIYKZFLDTAMW-GFCCVEGCSA-N
InChi Code: InChI=1S/C16H21N3O2S/c1-12(17)13-6-9-19(10-7-13)22(20,21)16-4-2-3-14-11-18-8-5-15(14)16/h2-5,8,11-13H,6-7,9-10,17H2,1H3/t12-/m1/s1
SMILES Code: O=S(C1=CC=CC2=CN=CC=C21)(N3CCC([C@@H](C)N)CC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 319.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. PMID: 31446620; PMCID: PMC7036327.
2: Bond LM, Sellers JR, McKerracher L. Rho kinase as a target for cerebral vascular disorders. Future Med Chem. 2015;7(8):1039-53. doi: 10.4155/fmc.15.45. PMID: 26062400; PMCID: PMC4656981.