WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464459
CAS#: 1434515-70-4
Description: UCSF924 is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC is the recommended negative control compound with a 1/2500-fold reduced D4 affinity.
Hodoodo Cat#: H464459
Name: UCSF924
CAS#: 1434515-70-4
Chemical Formula: C20H22N2O2
Exact Mass: 322.17
Molecular Weight: 322.408
Elemental Analysis: C, 74.51; H, 6.88; N, 8.69; O, 9.92
Synonym: UCSF924; UCSF 924; UCSF-924; 9-6-24; ZINC000091726127; ZINC 000091726127; ZINC-000091726127;
IUPAC/Chemical Name: 6-methyl-2-(((3-phenoxypropyl)amino)methyl)quinolin-4(1H)-one
InChi Key: RPHDOVLXDYWDGF-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H22N2O2/c1-15-8-9-19-18(12-15)20(23)13-16(22-19)14-21-10-5-11-24-17-6-3-2-4-7-17/h2-4,6-9,12-13,21H,5,10-11,14H2,1H3,(H,22,23)
SMILES Code: O=C1C=C(CNCCCOC2=CC=CC=C2)NC3=CC=C(C)C=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.0 | 124.00 |
The following data is based on the product molecular weight 322.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
