WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464560
CAS#: 2132411-21-1
Description: QD-394 is an inducer of reactive oxygen species (ROS) production. It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 µM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 µM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
Hodoodo Cat#: H464560
Name: QD-394
CAS#: 2132411-21-1
Chemical Formula: C19H19N5O2
Exact Mass: 349.15
Molecular Weight: 349.394
Elemental Analysis: C, 65.32; H, 5.48; N, 20.04; O, 9.16
Synonym: QD-394; QD394 QD 394;
IUPAC/Chemical Name: 6-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazoline-5,8-dione
InChi Key: INZGOHBCPALCGM-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19N5O2/c1-23-6-8-24(9-7-23)14-4-2-13(3-5-14)22-16-10-17(25)18-15(19(16)26)11-20-12-21-18/h2-5,10-12,22H,6-9H2,1H3
SMILES Code: O=C1C=C(NC2=CC=C(C=C2)N3CCN(C)CC3)C(C4=CN=CN=C14)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMF | 1.0 | 2.90 | |
DMSO | 5.0 | 14.00 | |
DMSO:PBS (pH 7.2) (1:20) | 0.0 | 0.11 | |
Ethanol | 1.0 | 2.90 |
The following data is based on the product molecular weight 349.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hu S, Sechi M, Singh PK, Dai L, McCann S, Sun D, Ljungman M, Neamati N. A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species. J Med Chem. 2020 Sep 10;63(17):9838-9855. doi: 10.1021/acs.jmedchem.0c01016. Epub 2020 Aug 28. PMID: 32809827.