WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H111001
CAS#: 82475-09-0
Description: OA 6129C is a new carbapenem antibiotic.
Hodoodo Cat#: H111001
Name: OA 6129C
CAS#: 82475-09-0
Chemical Formula: C20H31N3O11S2
Exact Mass: 553.14
Molecular Weight: 553.598
Elemental Analysis: C, 43.39; H, 5.64; N, 7.59; O, 31.79; S, 11.58
Synonym: OA 6129C; OA-6129C; OA6129C; Antibiotic OA 6129C; Antibiotic OA-6129C; Antibiotic OA6129C;
IUPAC/Chemical Name: 3-((2-(3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanamido)ethyl)thio)-7-oxo-6-(1-(sulfooxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
InChi Key: GRWWKENHBQJAML-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H31N3O11S2/c1-10(34-36(31,32)33)14-11-8-12(15(19(29)30)23(11)18(14)28)35-7-6-21-13(25)4-5-22-17(27)16(26)20(2,3)9-24/h10-11,14,16,24,26H,4-9H2,1-3H3,(H,21,25)(H,22,27)(H,29,30)(H,31,32,33)
SMILES Code: CC(C1C2CC(SCCNC(CCNC(C(C(C)(CO)C)O)=O)=O)=C(C(O)=O)N2C1=O)OS(=O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 553.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kojima I, Fukagawa Y, Okabe M, Ishikura T, Shibamoto N. Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems. J Antibiot (Tokyo). 1988 Jul;41(7):899-907. doi: 10.7164/antibiotics.41.899. PMID: 3417564.
2: Kubo K, Ishikura T, Fukagawa Y. Microbial phosphorylation of the OA-6129 group of carbapenem compounds. J Antibiot (Tokyo). 1985 Mar;38(3):333-9. doi: 10.7164/antibiotics.38.333. PMID: 3839225.
3: Kubo K, Ishikura T, Fukagawa Y. Studies on the biosynthesis of carbapenem antibiotics. II. Isolation and functions of a specific acylase involved in the depantothenylation of the OA-6129 compounds. J Antibiot (Tokyo). 1984 Nov;37(11):1394-402. doi: 10.7164/antibiotics.37.1394. PMID: 6511667.
4: Fukagawa Y, Okabe M, Azuma S, Kojima I, Ishikura T, Kubo K. Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the OA-6129 group of carbapenem compounds as the direct precursors for PS-5, epithienamycins A and C and MM 17880. J Antibiot (Tokyo). 1984 Nov;37(11):1388-93. doi: 10.7164/antibiotics.37.1388. PMID: 6511666.
5: Yoshioka T, Kojima I, Isshiki K, Watanabe A, Shimauchi Y, Okabe M, Fukagawa Y, Ishikura T. Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics produced by Streptomyces sp. OA-6129. J Antibiot (Tokyo). 1983 Nov;36(11):1473-82. doi: 10.7164/antibiotics.36.1473. PMID: 6654757.
6: Okabe M, Azuma S, Kojima I, Kouno K, Okamoto R, Fukagawa Y, Ishikura T. Studies on the OA-6129 group of antibiotics, new carbapenem compounds. I. Taxonomy, isolation and physical properties. J Antibiot (Tokyo). 1982 Oct;35(10):1255-63. doi: 10.7164/antibiotics.35.1255. PMID: 7174513.
