10B12

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H465203

CAS#: unknown

Description: 10B12 is a PKC Activator. 10B12 is a DAG-lactone with an isoxazole ring, binds PKCα and PKCε with nanomolar affinity. Remarkably, 10B12 displays preferential selectivity for PKCε translocation in cells and induces a PKCε-dependent reorganization of the actin cytoskeleton into peripheral ruffles in lung cancer cells.

Chemical Structure

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10B12
CAS# unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H465203
Name: 10B12
CAS#: unknown
Chemical Formula: C21H33NO5
Exact Mass: 379.24
Molecular Weight: 379.497
Elemental Analysis: C, 66.46; H, 8.77; N, 3.69; O, 21.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 10B12; 10 B12; 10-B12;

IUPAC/Chemical Name: (E)-5-(hydroxymethyl)-3-(3-isobutyl-5-methylhexylidene)-5-(((5-methylisoxazol-3-yl)oxy)methyl)dihydrofuran-2(3H)-one

InChi Key: COPQMLDDHGHTAG-CNHKJKLMSA-N

InChi Code: InChI=1S/C21H33NO5/c1-14(2)8-17(9-15(3)4)6-7-18-11-21(12-23,26-20(18)24)13-25-19-10-16(5)27-22-19/h7,10,14-15,17,23H,6,8-9,11-13H2,1-5H3/b18-7+

SMILES Code: O=C1OC(COC2=NOC(C)=C2)(CO)C/C1=C\CC(CC(C)C)CC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 379.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Elhalem E, Bellomo A, Cooke M, Scravaglieri A, Pearce LV, Peach ML, Gandolfi Donadío L, Kazanietz MG, Comin MJ. Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators. J Med Chem. 2021 Jul 19. doi: 10.1021/acs.jmedchem.1c00739. Epub ahead of print. PMID: 34279947.