WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465379
CAS#: unknown
Description: QLS-81 is a novel Nav1.7 channel blocker (IC50 at 3.5±1.5 μM). being efficacious on chronic pain in mice.
Hodoodo Cat#: H465379
Name: QLS-81
CAS#: unknown
Chemical Formula: C19H23FN2O2
Exact Mass: 330.17
Molecular Weight: 330.403
Elemental Analysis: C, 69.07; H, 7.02; F, 5.75; N, 8.48; O, 9.68
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Synonym: QLS-81; QLS81; QLS 81;
IUPAC/Chemical Name: (S)-2-((3-(4-((2-fluorobenzyl)oxy)phenyl)propyl)amino)propanamide
InChi Key: BGUNLGHCPLPUHW-AWEZNQCLSA-N
InChi Code: InChI=1S/C19H23FN2O2/c1-14(19(21)23)22-12-4-5-15-8-10-17(11-9-15)24-13-16-6-2-3-7-18(16)20/h2-3,6-11,14,22H,4-5,12-13H2,1H3,(H2,21,23)/t14-/m0/s1
SMILES Code: C[C@H](NCCCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 330.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Niu HL, Liu YN, Xue DQ, Dong LY, Liu HJ, Wang J, Zheng YL, Zou AR, Shao LM, Wang K. Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain. Acta Pharmacol Sin. 2021 Aug;42(8):1235-1247. doi: 10.1038/s41401-021-00682-9. Epub 2021 Jun 8. PMID: 34103689; PMCID: PMC8285378.