WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H414742
CAS#: 544-31-0
Description: Palmidrol is a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection.
Hodoodo Cat#: H414742
Name: Palmidrol
CAS#: 544-31-0
Chemical Formula: C18H37NO2
Exact Mass: 299.28
Molecular Weight: 299.490
Elemental Analysis: C, 72.19; H, 12.45; N, 4.68; O, 10.68
Synonym: Palmidrol; NSC 23320; NSC23320; NSC-23320; Palmitoylethanolamide
IUPAC/Chemical Name: N-(2-Hydroxyethyl)hexadecanamide
InChi Key: HXYVTAGFYLMHSO-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
SMILES Code: CCCCCCCCCCCCCCCC(NCCO)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 299.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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2: Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH. Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis. Pain Physician. 2017 Jul;20(5):353-362. PMID: 28727699.
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5: Gabrielsson L, Mattsson S, Fowler CJ. Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol. 2016 Oct;82(4):932-42. doi: 10.1111/bcp.13020. Epub 2016 Jun 29. PMID: 27220803; PMCID: PMC5094513.
6: Petrosino S, Di Marzo V. The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. Br J Pharmacol. 2017 Jun;174(11):1349-1365. doi: 10.1111/bph.13580. Epub 2016 Sep 29. PMID: 27539936; PMCID: PMC5429331.
7: Adornetto A, Rombolà L, Morrone LA, Nucci C, Corasaniti MT, Bagetta G, Russo R. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma. Nutrients. 2020 Oct 16;12(10):3158. doi: 10.3390/nu12103158. PMID: 33081127; PMCID: PMC7602834.
8: Ye S, Chen Q, Jiang N, Liang X, Li J, Zong R, Huang C, Qiu Y, Ma JX, Liu Z. PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis. Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):15. doi: 10.1167/iovs.61.4.15. PMID: 32298438; PMCID: PMC7401460.
9: De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, Di Marzo V. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol. 2011 Aug;163(7):1479-94. doi: 10.1111/j.1476-5381.2010.01166.x. PMID: 21175579; PMCID: PMC3165957.
10: Stensson N, Gerdle B, Ernberg M, Mannerkorpi K, Kosek E, Ghafouri B. Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia. Med Sci Sports Exerc. 2020 Jul;52(7):1617-1628. doi: 10.1249/MSS.0000000000002293. PMID: 32168104.
