WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465432
CAS#: unknown
Description: OAN00639 is a novel Potent PD-L1 Inhibitor (IC50 1.8 nM), binding to human PD-L1 (hPD-L1) with a KD value of 3.34 nM, without showing any binding to hPD-1, blocking PD-1/PD-L1 interaction with an EC50 value of 375 nM.
Hodoodo Cat#: H465432
Name: OAN00639
CAS#: unknown
Chemical Formula: C30H25BrClN3O6
Exact Mass: 637.06
Molecular Weight: 638.899
Elemental Analysis: C, 56.40; H, 3.94; Br, 12.51; Cl, 5.55; N, 6.58; O, 15.02
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Synonym: OAN00639; OAN 00639; OAN-00639; PD-L1 Inhibitor L7;
IUPAC/Chemical Name: (2-(benzo[c][1,2,5]oxadiazol-5-ylmethoxy)-4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chlorobenzyl)-D-serine
InChi Key: OUHGBSZZOWVTDI-AREMUKBSSA-N
InChi Code: InChI=1S/C30H25BrClN3O6/c31-29-20(7-4-8-22(29)19-5-2-1-3-6-19)17-40-28-13-27(21(12-23(28)32)14-33-26(15-36)30(37)38)39-16-18-9-10-24-25(11-18)35-41-34-24/h1-13,26,33,36H,14-17H2,(H,37,38)/t26-/m1/s1
SMILES Code: OC[C@H](C(O)=O)NCC1=CC(Cl)=C(OCC2=C(Br)C(C3=CC=CC=C3)=CC=C2)C=C1OCC4=CC5=NON=C5C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 638.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Liu L, Yao Z, Wang S, Xie T, Wu G, Zhang H, Zhang P, Wu Y, Yuan H, Sun H. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64(12):8391-8409. doi: 10.1021/acs.jmedchem.1c00392. Epub 2021 Jun 11. PMID: 34115499.