WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465713
CAS#: 1777792-33-2
Description: ATX-001 is an ionizable lipid. It is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine Delivery.
Hodoodo Cat#: H465713
Name: ATX-001
CAS#: 1777792-33-2
Chemical Formula: C40H74N2O5S
Exact Mass: 694.53
Molecular Weight: 695.101
Elemental Analysis: C, 69.12; H, 10.73; N, 4.03; O, 11.51; S, 4.61
Synonym: ATX-001; ATX001; ATX 001;
IUPAC/Chemical Name: di((Z)-non-2-en-1-yl) 8,8'-((2-((2-(dimethylamino)ethyl)thio)acetyl)azanediyl)dioctanoate
InChi Key: PSYGHBKNZFCYQB-ZDSKVHJSSA-N
InChi Code: InChI=1S/C40H74N2O5S/c1-5-7-9-11-13-21-27-34-46-39(44)29-23-17-15-19-25-31-42(38(43)37-48-36-33-41(3)4)32-26-20-16-18-24-30-40(45)47-35-28-22-14-12-10-8-6-2/h21-22,27-28H,5-20,23-26,29-37H2,1-4H3/b27-21-,28-22-
SMILES Code: O=C(CSCCN(C)C)N(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 250.0 | 359.66 |
The following data is based on the product molecular weight 695.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Balupuri A, Lee MH, Chae S, Jung E, Yoon W, Kim Y, Son SJ, Ryu J, Kang DH, Yang YJ, You JN, Kwon H, Jeong JW, Koo TS, Lee DY, Kang NS. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem. 2018 Mar 25;148:397-409. doi: 10.1016/j.ejmech.2018.02.049. Epub 2018 Feb 17. PMID: 29477073. |
| In vitro protocol: | 1. Balupuri A, Lee MH, Chae S, Jung E, Yoon W, Kim Y, Son SJ, Ryu J, Kang DH, Yang YJ, You JN, Kwon H, Jeong JW, Koo TS, Lee DY, Kang NS. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem. 2018 Mar 25;148:397-409. doi: 10.1016/j.ejmech.2018.02.049. Epub 2018 Feb 17. PMID: 29477073. |
| In vivo protocol: | TBD |
1. Balupuri A, Lee MH, Chae S, Jung E, Yoon W, Kim Y, Son SJ, Ryu J, Kang DH, Yang YJ, You JN, Kwon H, Jeong JW, Koo TS, Lee DY, Kang NS. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem. 2018 Mar 25;148:397-409. doi: 10.1016/j.ejmech.2018.02.049. Epub 2018 Feb 17. PMID: 29477073.
