• CAT# 206112
  • CAS# 1420477-60-6
  • Purity 98%

Price and availability


Structure of Acalabrutinib

CAS# 1420477-60-6

Size Price Availability Quantity
0.1 g$ 150

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0.2 g$ 250

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0.5 g$ 450

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1 g$ 750

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2 g$ 1250

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$1,250.00Add to cart

5 g$ 2050

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10 g$ 3450

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20 g$ 5850

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Pricing updated 2019-06-25 . Prices are subject to change without notice

Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Technical data

IUPAC/Chemnical Name(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N
Synonym nameAcalabrutinib; ACP-196; ACP196; ACP 196;
Molecule FormlaC26H23N7O2
Molecule Weight465.5170
AppearanceWhite to off-white solid powder
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage ConditionDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Stability>2 years if stored properly
Harmonized System (HS) Code 2916.39.79.00
SMILES code O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
InChi codeInChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s