Acalabrutinib
- CAT# 206112
- CAS# 1420477-60-6
- Purity 98%
Price and availability
Structure
Structure of Acalabrutinib
CAS# 1420477-60-6
Size Price Availability Quantity 0.1 g $ 150 same day
$150.00Add to cart
0.2 g $ 250 same day
$250.00Add to cart
0.5 g $ 450 same day
$450.00Add to cart
1 g $ 750 same day
$750.00Add to cart
2 g $ 1250 same day
$1,250.00Add to cart
5 g $ 2050 same day
$2,050.00Add to cart
10 g $ 3450 same day
$3,450.00Add to cart
20 g $ 5850 same day
$5,850.00Add to cart
Pricing updated 2019-06-25 . Prices are subject to change without notice
Description:
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Technical data
IUPAC/Chemnical Name (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N Synonym name Acalabrutinib; ACP-196; ACP196; ACP 196; CAS# 1420477-60-6 PubChem# 71226662 Molecule Formla C26H23N7O2 Molecule Weight 465.5170 Appearance White to off-white solid powder Purity 98% Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stability >2 years if stored properly Harmonized System (HS) Code 2916.39.79.00 SMILES code O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2 InChi code InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s InChi key WDENQIQQYWYTPO-IBGZPJMESA-N
Structure of Acalabrutinib
CAS# 1420477-60-6
Size | Price | Availability | Quantity | |
---|---|---|---|---|
0.1 g | $ 150 | same day | $150.00Add to cart | |
0.2 g | $ 250 | same day | $250.00Add to cart | |
0.5 g | $ 450 | same day | $450.00Add to cart | |
1 g | $ 750 | same day | $750.00Add to cart | |
2 g | $ 1250 | same day | $1,250.00Add to cart | |
5 g | $ 2050 | same day | $2,050.00Add to cart | |
10 g | $ 3450 | same day | $3,450.00Add to cart | |
20 g | $ 5850 | same day | $5,850.00Add to cart |
Description:
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Technical data
IUPAC/Chemnical Name | (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N |
Synonym name | Acalabrutinib; ACP-196; ACP196; ACP 196; |
CAS# | 1420477-60-6 |
PubChem# | 71226662 |
Molecule Formla | C26H23N7O2 |
Molecule Weight | 465.5170 |
Appearance | White to off-white solid powder |
Purity | 98% |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Stability | >2 years if stored properly |
Harmonized System (HS) Code | 2916.39.79.00 |
SMILES code | O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2 |
InChi code | InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s |
InChi key | WDENQIQQYWYTPO-IBGZPJMESA-N |