WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H112004
CAS#: 355406-09-6
Description: YM-155 is a survivin inhibitor. It inhibits survivin promoter activity in a reporter assay (IC50 = 0.54 nM). YM-155 (10-1,000 nM) reduces survivin levels and induces apoptosis in PC3 and PPC-1 prostate cancer cells. In vivo, YM-155 (3 and 10 mg/kg) inhibits tumor growth, decreases intratumor survivin levels, and induces tumor regression in a PC3 mouse xenograft model. It reduces tumor volume in a MiaPaCa-2 pancreatic cancer mouse xenograft model. YM-155 also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro; IC50 = 2.47 µM) and reduces the number of viral RNA copies in SARS-CoV-2-infected Vero E6 cells.
Hodoodo Cat#: H112004
Name: YM-155 Cl
CAS#: 355406-09-6
Chemical Formula: C20H19ClN4O3
Exact Mass: 0.00
Molecular Weight: 398.850
Elemental Analysis: C, 60.23; H, 4.80; Cl, 8.89; N, 14.05; O, 12.03
Synonym: YM-155 Cl; YM-155 chloride; YM-155-Cl; YM155 Cl; YM 155 Cl; YM-155
IUPAC/Chemical Name: 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium chloride
InChi Key: NUZWGSASIPTGSA-UHFFFAOYSA-M
InChi Code: InChI=1S/C20H19N4O3.ClH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
SMILES Code: O=C1C2=C([N+](CC3=NC=CN=C3)=C(C)N2CCOC)C(C4=CC=CC=C41)=O.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| PBS (pH: 7.2) | 5.0 | 12.54 |
The following data is based on the product molecular weight 398.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Murakami Y, Matsuya T, Kita A, Yamanaka K, Noda A, Mitsuoka K, Nakahara T, Miyoshi S, Nishimura S. Radiosynthesis, biodistribution and imaging of [11C]YM155, a novel survivin suppressant, in a human prostate tumor-xenograft mouse model. Nucl Med Biol. 2013 Feb;40(2):221-6. doi: 10.1016/j.nucmedbio.2012.10.002. Epub 2012 Nov 7. PMID: 23141550.
