WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H112022
CAS#: 110064-71-6
Description: 12-Epinapelline is a diterpenoid alkaloid that has been found in Aconitum and has antiarrhythmic activity. It has antiarrhythmic activity in a rat model of aconitine-induced arrhythmia and antifibrillatory activity in a mouse model of aconitine-induced cardiac fibrillation (ED50s = 8 and 20 mg/kg, respectively).
Hodoodo Cat#: H112022
Name: 12-Epinapelline
CAS#: 110064-71-6
Chemical Formula: C22H33NO3
Exact Mass: 359.246
Molecular Weight: 359.51
Elemental Analysis: C, 73.50; H, 9.25; N, 3.90; O, 13.35
Synonym: 12 epi Napelline; 12epi Napelline; 12-epi Napelline; 12-Epinapelline; 12Epinapelline; 12 Epinapelline
IUPAC/Chemical Name: (3R,6S,6aS,6bR,8R,9R,11R,11aR,12R,12aR,14R)-1-ethyl-3-methyl-10-methylenetetradecahydro-3,6a,12-(epiethane[1,1,2]triyl)-9,11a-methanoazuleno[2,1-b]azocine-6,8,11-triol
InChi Key: AZAZKLKDEOMJBJ-PQNIRSBSSA-N
InChi Code: InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3/t12-,13+,14-,15-,16-,17+,18-,19-,20+,21+,22-/m1/s1
SMILES Code: O[C@@H]1[C@@]23[C@]4([C@@]5([C@@H]6[C@]2(N(CC)C[C@@](CC1)(C)[C@H]3C6)[H])C[C@@H]([C@H](O)C4)C([C@H]5O)=C)[H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Chloroform | 10.0 | 27.82 |
The following data is based on the product molecular weight 359.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nesterova YV, Povet'yeva TN, Suslov NI, Zyuz'kov GN, Pushkarskii SV, Aksinenko SG, Schultz EE, Kravtsova SS, Krapivin AV. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bull Exp Biol Med. 2014 Aug;157(4):488-91. doi: 10.1007/s10517-014-2598-6. Epub 2014 Aug 12. PMID: 25110090.
2: Nesterova YV, Povetieva TN, Suslov NI, Zyuz'kov GN, Aksinenko SG, Pushkarskii SV, Krapivin AV. Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense. Bull Exp Biol Med. 2014 Mar;156(5):665-8. doi: 10.1007/s10517-014-2421-4. Epub 2014 Mar 30. PMID: 24770754.
3: Nesterova YV, Povetieva TN, Suslov NI, Zhdanov VV, Hrichkova TY, Udut EV, Chaykovskiy AS, Gaydamovich NN, Andreeva TI, Dygai AM. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bull Exp Biol Med. 2012 Feb;152(4):439-43. English, Russian. doi: 10.1007/s10517-012-1548-4. PMID: 22803106.
