QLN49417

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H208114

CAS#: 220749-41-7

Description: QLN49417, also known as CDK1 inhibitor 8a, is a selective CDK1 inhibitor. This compound was first reported by Andreani, Aldo; et al in Anti-Cancer Drug Design (2001), 15(6), 447-452. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to Hodoodo Chemical Nomenclature (see web page: https://www.hodoodo.com/page/naming).


Chemical Structure

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QLN49417
CAS# 220749-41-7

Theoretical Analysis

Hodoodo Cat#: H208114
Name: QLN49417
CAS#: 220749-41-7
Chemical Formula: C17H11ClN2O
Exact Mass: 294.06
Molecular Weight: 294.740
Elemental Analysis: C, 69.28; H, 3.76; Cl, 12.03; N, 9.50; O, 5.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CDK1 inhibitor 8a; CDK1inhibitor8a; CDK1-inhibitor-8a, Cdk1 Inhibitor; QLN49417; QLN-49417; QLN 49417;

IUPAC/Chemical Name: (Z)-3-((2-chloro-1H-indol-3-yl)methylene)indolin-2-one

InChi Key: QJKBRWSJWQVKLY-LCYFTJDESA-N

InChi Code: InChI=1S/C17H11ClN2O/c18-16-12(10-5-1-3-7-14(10)19-16)9-13-11-6-2-4-8-15(11)20-17(13)21/h1-9,19H,(H,20,21)/b13-9-

SMILES Code: ClC(N1)=C(/C=C2C(C=CC=C3)=C3NC/2=O)C4=C1C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 294.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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6: Lu PH, Yu CC, Chiang PC, Chen YC, Ho YF, Kung FL, Guh JH. Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer. J Urol. 2011 Dec;186(6):2434-41. doi: 10.1016/j.juro.2011.07.088. Epub 2011 Oct 21. PMID: 22019170.
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