WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556106
CAS#: 98636-73-8 (HCl)
Description: Nitrocaramiphen is a muscarinic antagonist with 71-fold selectivity for M1 over M2.
Hodoodo Cat#: H556106
Name: Nitrocaramiphen HCl
CAS#: 98636-73-8 (HCl)
Chemical Formula: C18H27ClN2O4
Exact Mass: 0.00
Molecular Weight: 370.874
Elemental Analysis: C, 58.29; H, 7.34; Cl, 9.56; N, 7.55; O, 17.26
Related CAS #: 98636-73-8 (HCl) 135569-16-3 (free base)
Synonym: Nitrocaramiphen HCl; Nitrocaramiphen hydrochloride; Nitrocaramiphen;
IUPAC/Chemical Name: 2-Diethylaminoethyl 1-(4-nitrophenyl)cyclopentanecarboxylate hydrochloride
InChi Key: XWQWACGTGFICFO-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H26N2O4.ClH/c1-3-19(4-2)13-14-24-17(21)18(11-5-6-12-18)15-7-9-16(10-8-15)20(22)23;/h7-10H,3-6,11-14H2,1-2H3;1H
SMILES Code: O=C(C1(C2=CC=C([N+]([O-])=O)C=C2)CCCC1)OCCN(CC)CC.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 370.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Naumenko NV, Malomuzh AI, Khairova RA, Zefirov AL, Urazaev AKh. Farmakologicheskie osobennosti muskarinovykh cholinoretseptorov skeletnykh myshts [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):619-26. Russian. PMID: 12136730.
2: Reaper CM, Fanelli F, Buckingham SD, Millar NS, Sattelle DB. Antagonist profile and molecular dynamic simulation of a Drosophila melanogaster muscarinic acetylcholine receptor. Recept Channels. 1998;5(6):331-45. PMID: 9826910.
3: Hudkins RL, Stubbins JF, DeHaven-Hudkins DL. Caramiphen, iodocaramiphen and nitrocaramiphen are potent, competitive, muscarinic M1 receptor-selective agents. Eur J Pharmacol. 1993 Feb 16;231(3):485-8. doi: 10.1016/0014-2999(93)90130-a. PMID: 8449241.
4: Hudkins RL, DeHaven-Hudkins DL. M1 muscarinic antagonists interact with sigma recognition sites. Life Sci. 1991;49(17):1229-35. doi: 10.1016/0024-3205(91)90135-x. Erratum in: Life Sci 1992;50(3):245. PMID: 1658507.