WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H207180
CAS#: 2654743-22-1
Description: MRTX0902 is a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein−Protein Interaction. Oral administration of MRTX0902 in combination with MRTX849 results in a significant increase in antitumor activity relative to that of either single agent, including tumor regressions in a subset of animals in the MIA PaCa-2 tumor mouse xenograft model.
Hodoodo Cat#: H207180
Name: MRTX0902
CAS#: 2654743-22-1
Chemical Formula: C22H24N6O
Exact Mass: 388.2012
Molecular Weight: 388.475
Elemental Analysis: C, 68.02; H, 6.23; N, 21.63; O, 4.12
Related CAS #: 2654743-22-1
Synonym: MRTX0902; MRTX-0902; MRTX 0902;
IUPAC/Chemical Name: (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido-[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile
InChi Key: ILPWEAHQRAWJIU-OAHLLOKOSA-N
InChi Code: InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1
SMILES Code: N#CC1=CC=CC([C@H](NC2=NN=C(C)C3=CN=C(N4CCOCC4)C=C32)C)=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 388.475 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
