MRTX0902
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H207180

CAS#: 2654743-22-1

Description: MRTX0902 is a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein−Protein Interaction. Oral administration of MRTX0902 in combination with MRTX849 results in a significant increase in antitumor activity relative to that of either single agent, including tumor regressions in a subset of animals in the MIA PaCa-2 tumor mouse xenograft model.


Chemical Structure

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MRTX0902
CAS# 2654743-22-1

Theoretical Analysis

Hodoodo Cat#: H207180
Name: MRTX0902
CAS#: 2654743-22-1
Chemical Formula: C22H24N6O
Exact Mass: 388.2012
Molecular Weight: 388.475
Elemental Analysis: C, 68.02; H, 6.23; N, 21.63; O, 4.12

Price and Availability

Size Price Availability Quantity
25.0mg USD 750.0 2 Weeks
50.0mg USD 1250.0 2 Weeks
100.0mg USD 2150.0 2 Weeks
200.0mg USD 3250.0 2 Weeks
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Synonym: MRTX0902; MRTX-0902; MRTX 0902;

IUPAC/Chemical Name: (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido-[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile

InChi Key: ILPWEAHQRAWJIU-OAHLLOKOSA-N

InChi Code: InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1

SMILES Code: N#CC1=CC=CC([C@H](NC2=NN=C(C)C3=CN=C(N4CCOCC4)C=C32)C)=C1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Instruction:

Preparing Stock Solutions

The following data is based on the product molecular weight 388.475 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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MRTX0902

25.0mg / USD 750.0