WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556121
CAS#: 331859-86-0
Description: Chromeceptin is an IGF2 inhibitor. Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.
Hodoodo Cat#: H556121
Name: Chromeceptin
CAS#: 331859-86-0
Chemical Formula: C19H16F3N3O
Exact Mass: 359.1245
Molecular Weight: 359.3522
Elemental Analysis: C, 63.51; H, 4.49; F, 15.86; N, 11.69; O, 4.45
Synonym: Chromeceptin; 94G6;
IUPAC/Chemical Name: 2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene
InChi Key: GVINXTXGDDSXFQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3
SMILES Code: FC(C1=CC(C2C(C#N)=C(N)OC3=C2C=CC(N(C)C)=C3)=CC=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 359.3522 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhao Y, Xiong Z, Chen Y, Wang G, Zhao Y. Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy. Neuroimmunomodulation. 2021;28(4):266-275. doi: 10.1159/000515662. Epub 2021 May 5. PMID: 33951651.
2: Seol HS, Akiyama Y, Lee SE, Shimada S, Jang SJ. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10(1):21412. doi: 10.1038/s41598-020-77960-9. PMID: 33293585; PMCID: PMC7722933.
3: Park YS, Kim HS, Kim JH, Choi SH, Kim DS, Ryoo ZY, Kim JY, Lee S. NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation. Biochem Biophys Res Commun. 2020 May 28;526(2):287-292. doi: 10.1016/j.bbrc.2020.03.090. Epub 2020 Mar 23. PMID: 32216968.
4: Fanganiello RD, Ishiy FA, Kobayashi GS, Alvizi L, Sunaga DY, Passos-Bueno MR. Increased In Vitro Osteopotential in SHED Associated with Higher IGF2 Expression When Compared with hASCs. Stem Cell Rev Rep. 2015 Aug;11(4):635-44. doi: 10.1007/s12015-015-9592-x. PMID: 25931278.
5: Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15;448(3):409-16. doi: 10.1042/BJ20121158. PMID: 23067267.
6: Uesugi M. [Control and analysis of cells by synthetic small molecules]. Yakugaku Zasshi. 2012;132(5):575-86. Japanese. doi: 10.1248/yakushi.132.575. PMID: 22687693.
7: Ma N, Wang X, Qiao Y, Li F, Hui Y, Zou C, Jin J, Lv G, Peng Y, Wang L, Huang H, Zhou L, Zheng X, Gao X. Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner. Mol Cell Endocrinol. 2011 Feb 10;333(1):96-101. doi: 10.1016/j.mce.2010.11.027. Epub 2010 Dec 10. PMID: 21146586.
8: Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M. Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol. 2006 Mar;13(3):241-9. doi: 10.1016/j.chembiol.2005.12.011. PMID: 16638529.
