WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208288
CAS#: unknown
Description: F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor. Using in vitro and ex vivo models of GBM, researchers found that F114 inhibits GBM proliferation and invasion. These results establish F114 as a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future drug development efforts for GBM, and potentially other cancers.
Hodoodo Cat#: H208288
Name: F114
CAS#: unknown
Chemical Formula: C16H20N6O
Exact Mass: 312.17
Molecular Weight: 312.380
Elemental Analysis: C, 61.52; H, 6.45; N, 26.90; O, 5.12
This product is not in stock, which may be available by custom synthesis.
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Synonym: F-114, F1-14, F11-4
IUPAC/Chemical Name: 8-Isopropyl-2-((1-isopropyl-1H-pyrazol-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChi Key: WANOQCJEBRGYPS-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H20N6O/c1-10(2)21-9-13(8-18-21)19-16-17-7-12-5-6-14(23)22(11(3)4)15(12)20-16/h5-11H,1-4H3,(H,17,19,20)
SMILES Code: CC(C)N1N=CC(NC2=NC(N(C(C)C)C(C=C3)=O)=C3C=N2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 312.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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