WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556129
CAS#: 181223-80-3 (free base)
Description: DEL-22379 is a potent and selective ERK Dimerization inhibitor. DEL-22379 inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a valid strategy for antineoplastic intervention.
Hodoodo Cat#: H556129
Name: DEL22379
CAS#: 181223-80-3 (free base)
Chemical Formula: C26H28N4O3
Exact Mass: 444.2161
Molecular Weight: 444.53
Elemental Analysis: C, 70.25; H, 6.35; N, 12.60; O, 10.80
Related CAS #: 181223-80-3 (free base) DEL22379 HCl
Synonym: DEL22379; DEL-22379; DEL 22379;
IUPAC/Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
InChi Key: INQUULPXCZAKMS-LPYMAVHISA-N
InChi Code: InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21)29-26(22)32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8,13-16,27H,2-4,9-12H2,1H3,(H,28,31)(H,29,32)/b22-13+
SMILES Code: O=C(NC1=CC2=C(NC(/C2=C/C3=CNC4=C3C=C(OC)C=C4)=O)C=C1)CCN5CCCCC5
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 444.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zaballos MA, Acuña-Ruiz A, Morante M, Riesco-Eizaguirre G, Crespo P, Santisteban P. Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer. Cell Mol Life Sci. 2022 Sep 3;79(9):504. doi: 10.1007/s00018-022-04530-9. PMID: 36056964; PMCID: PMC9440884.
2: Yang Y, Zhou Y, Tao L, Yang T, Zhao Y, Luo Y. Structure-activity relationship study of DEL-22379: ERK dimerization inhibitors with increased safety. Mol Divers. 2021 May;25(2):1051-1075. doi: 10.1007/s11030-020-10088-0. Epub 2020 May 6. PMID: 32377992.
