WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556132
CAS#: 1201916-31-5
Description: TCS-2210 is a small molecule inducer of neuronal differentiation. TCS-2210 increases expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells.
Hodoodo Cat#: H556132
Name: TCS-2210
CAS#: 1201916-31-5
Chemical Formula: C18H17N3O3
Exact Mass: 323.13
Molecular Weight: 323.350
Elemental Analysis: C, 66.86; H, 5.30; N, 13.00; O, 14.84
Synonym: TCS-2210; TCS 2210; TCS2210;
IUPAC/Chemical Name: 1,2-dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
InChi Key: ZOFZKGFBKISZRI-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17N3O3/c22-17(21-24)13-9-10-14-16(11-13)19-15(18(23)20-14)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-11,24H,4,7-8H2,(H,20,23)(H,21,22)
SMILES Code: O=C(C1=CC2=C(NC(C(CCCC3=CC=CC=C3)=N2)=O)C=C1)NO
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | TCS-2210 increased expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells. |
| In vitro activity: | This study identified TCS-2210, which induced a neuronal differentiation from mesenchymal stem cells (MSCs). Reference: J Med Chem. 2009 Dec 24;52(24):7931-3. https://pubmed.ncbi.nlm.nih.gov/20014867/ |
| In vivo activity: | To be determined |
The following data is based on the product molecular weight 323.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Kim NR, Kang SK, Ahn HH, Kwon SW, Park WS, Kim KS, Kim SS, Jung HJ, Choi SU, Ahn JH, Kim KR. Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558. PMID: 20014867. |
| In vitro protocol: | 1. Kim NR, Kang SK, Ahn HH, Kwon SW, Park WS, Kim KS, Kim SS, Jung HJ, Choi SU, Ahn JH, Kim KR. Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558. PMID: 20014867. |
| In vivo protocol: | To be determined |
