WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H406401
CAS#: 749234-11-5
Description: DMAT, also known as 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole, is a potent CK2 inhibitor, which shows anti-neoplastic effect on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. DMAT also induces cell death in antiestrogen resistant human breast cancer cells.
Hodoodo Cat#: H406401
Name: DMAT
CAS#: 749234-11-5
Chemical Formula: C9H7Br4N3
Exact Mass: 472.74
Molecular Weight: 476.790
Elemental Analysis: C, 22.67; H, 1.48; Br, 67.04; N, 8.81
Synonym: DMAT; 2dimethylamino4567tetrabromobenzimidazole.
IUPAC/Chemical Name: 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzo[d]imidazol-2-amine
InChi Key: SLPJGDQJLTYWCI-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15)
SMILES Code: CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 476.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sass G, Klinger N, Sirma H, Hashemolhosseini S, Hellerbrand C, Neureiter D, Wege H, Ocker M, Tiegs G. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42. doi: 10.3892/ijo.2011.1037. Epub 2011 May 10. PubMed PMID: 21567083.
2: Lawnicka H, Kowalewicz-Kulbat M, Sicinska P, Kazimierczuk Z, Grieb P, Stepien H. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(2):371-9. doi: 10.1007/s00441-010-0960-1. Epub 2010 Apr 6. PubMed PMID: 20383646.
3: Fritz G, Issinger OG, Olsen BB. Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses. Int J Oncol. 2009 Nov;35(5):1151-7. PubMed PMID: 19787270.
4: Schneider CC, Hessenauer A, Götz C, Montenarh M. DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks. Oncol Rep. 2009 Jun;21(6):1593-7. PubMed PMID: 19424641.
5: Yde CW, Frogne T, Lykkesfeldt AE, Fichtner I, Issinger OG, Stenvang J. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT. Cancer Lett. 2007 Oct 28;256(2):229-37. Epub 2007 Jul 16. PubMed PMID: 17629615.
