RPR203494

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H406338

CAS#: 218160-26-0

Description: RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.

Chemical Structure

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RPR203494
CAS# 218160-26-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H406338
Name: RPR203494
CAS#: 218160-26-0
Chemical Formula: C26H29FN6O4
Exact Mass: 508.22
Molecular Weight: 508.540
Elemental Analysis: C, 61.41; H, 5.75; F, 3.74; N, 16.53; O, 12.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RPR203494; RPR203494; RPR 203494.

IUPAC/Chemical Name: ((2r,5r)-2-(5-(2-(cyclopropylamino)pyrimidin-4-yl)-4-(4-fluorophenyl)-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl)(morpholino)methanone

InChi Key: RERSCSYZEKLVHG-OJBMAJLDSA-N

InChi Code: InChI=1S/C26H29FN6O4/c1-26(24(34)33-10-12-35-13-11-33)14-36-23(37-15-26)22-31-20(16-2-4-17(27)5-3-16)21(32-22)19-8-9-28-25(30-19)29-18-6-7-18/h2-5,8-9,18,23H,6-7,10-15H2,1H3,(H,31,32)(H,28,29,30)/t23-,26-

SMILES Code: O=C([C@]1(C)CO[C@@H](C2=NC(C3=CC=C(F)C=C3)=C(C4=NC(NC5CC5)=NC=C4)N2)OC1)N6CCOCC6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition: 0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly.

Drug Formulation: Stock solution storage:

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 508.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7. Compositions, combinations, and methods for treating cardiovascular conditions and other associated conditions. By Rudolph, Amy E.; Rocha, Ricardo; Carretero, Oscar. From U.S. Pat. Appl. Publ. (2004), US 20040167197 A1 20040826.

8. RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. By Collis, Alan J.; Foster, Martyn L.; Halley, Frank; Maslen, Christopher; McLay, Iain M.; Page, Kenneth M.; Redford, E. Jane; Souness, John E.; Wilsher, Nicola E.. From Bioorganic & Medicinal Chemistry Letters (2001), 11(5), 693-696. Language: English, Database: CAPLUS, DOI:10.1016/S0960-894X(01)00034-8

9. Preparation of imidazolyl-cyclic acetals as TNF-alpha inhibitor. By Bamborough, Paul Lindsay; Collis, Alan John; Halley, Frank; Lewis, Richard Alan; Lythgoe, David John; McKenna, Jeffrey Mark; Mclay, Iain Mcfarlane; Porter, Barry; Ratcliffe, Andrew James; Wallace, Paul Andrew. From PCT Int. Appl. (1998), WO 9856788 A1 19981217.