GSK1997132B

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H522542

CAS#: 1168138-37-1

Description: GSK1997132B is a potent, metabolically stable and centrally penetrant PPARγ partial agonist.


Chemical Structure

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GSK1997132B
CAS# 1168138-37-1

Theoretical Analysis

Hodoodo Cat#: H522542
Name: GSK1997132B
CAS#: 1168138-37-1
Chemical Formula: C24H22F2N4O
Exact Mass: 420.18
Molecular Weight: 420.460
Elemental Analysis: C, 68.56; H, 5.27; F, 9.04; N, 13.33; O, 3.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GSK 1997132B; GSK-1997132B; GSK1997132B; GSK1997132; GSK-1997132; GSK 1997132.

IUPAC/Chemical Name: (R)-1-((3,5-difluoropyridin-2-yl)methyl)-2-methyl-N-(1-phenylpropyl)-1H-benzo[d]imidazole-5-carboxamide

InChi Key: VYCNCLBUJAXONJ-HXUWFJFHSA-N

InChi Code: InChI=1S/C24H22F2N4O/c1-3-20(16-7-5-4-6-8-16)29-24(31)17-9-10-23-21(11-17)28-15(2)30(23)14-22-19(26)12-18(25)13-27-22/h4-13,20H,3,14H2,1-2H3,(H,29,31)/t20-/m1/s1

SMILES Code: O=C(C1=CC=C2N(CC3=NC=C(F)C=C3F)C(C)=NC2=C1)N[C@@H](C4=CC=CC=C4)CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 420.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH,
Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM,
Xu RX, Virley DJ. Discovery of GSK1997132B a novel centrally penetrant
benzimidazole PPARγ partial agonist. Bioorg Med Chem Lett. 2011 Sep
15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in:
Bioorg Med Chem Lett. 2013 Feb 15;23(4):1143. Wilson, Timothy M [corrected to
Willson, Timothy M]. PubMed PMID: 21798739.