WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206511
CAS#: 1636180-98-7 (bromide)
Description: Tarloxotinib bromide, also known TH-4000 or PR-610, is a prodrug designed to selectively release a covalent (irreversible) EGFR tyrosine kinase inhibitor under severe hypoxia, a feature of many solid tumors. Tarloxotinib has the potential to effectively shut down aberrant EGFR signaling in a tumor-selective manner, thus potentially avoiding or reducing the systemic side effects associated with currently available EGFR tyrosine kinase inhibitors.
Hodoodo Cat#: H206511
Name: Tarloxotinib bromide
CAS#: 1636180-98-7 (bromide)
Chemical Formula: C24H24Br2ClN9O3
Exact Mass: 0.00
Molecular Weight: 681.770
Elemental Analysis: C, 42.28; H, 3.55; Br, 23.44; Cl, 5.20; N, 18.49; O, 7.04
Related CAS #: 1636938-13-0 (cation) 1636180-98-7 (bromide)
Synonym: PR-610, PR 610, PR610, TH-4000, TH 4000, TH4000, Hypoxin, Tarloxotinib bromide, Tarloxotinib
IUPAC/Chemical Name: (E)-4-((4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)amino)-N,N-dimethyl-N-((1-methyl-4-nitro-1H-imidazol-5-yl)methyl)-4-oxobut-2-en-1-aminium bromide
InChi Key: WAKIMVYUBWMMHJ-FXRZFVDSSA-N
InChi Code: InChI=1S/C24H23BrClN9O3.BrH/c1-33-14-30-24(34(37)38)20(33)12-35(2,3)8-4-5-22(36)32-21-10-16-19(11-27-21)28-13-29-23(16)31-15-6-7-18(26)17(25)9-15;/h4-7,9-11,13-14H,8,12H2,1-3H3,(H-,27,28,29,31,32,36);1H/b5-4+;
SMILES Code: O=C(NC1=CC2=C(NC3=CC=C(Cl)C(Br)=C3)N=CN=C2C=N1)/C=C/C[N+](C)(C)CC4=C([N+]([O-])=O)N=CN4C.[Br-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.0 | 44.00 |
The following data is based on the product molecular weight 681.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |