WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407239
CAS#: 1788896-33-2
Description: NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly downregulated the expression of Gli2 which plays an important role in Hh pathway. NL-103 may be a promising compound for clinical development as a more effective Hh pathway inhibitor.
Hodoodo Cat#: H407239
Name: NL-103
CAS#: 1788896-33-2
Chemical Formula: C26H27Cl2N5O4
Exact Mass: 543.14
Molecular Weight: 544.430
Elemental Analysis: C, 57.36; H, 5.00; Cl, 13.02; N, 12.86; O, 11.75
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: NL-103; NL 103; NL103.
IUPAC/Chemical Name: N-(4-chloro-3-(3-chlorobenzamido)phenyl)-6-((7-(hydroxyamino)-7-oxoheptyl)amino)nicotinamide
InChi Key: RJWLMMYFBDEKDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H27Cl2N5O4/c27-19-7-5-6-17(14-19)25(35)32-22-15-20(10-11-21(22)28)31-26(36)18-9-12-23(30-16-18)29-13-4-2-1-3-8-24(34)33-37/h5-7,9-12,14-16,37H,1-4,8,13H2,(H,29,30)(H,31,36)(H,32,35)(H,33,34)
SMILES Code: O=C(C1=CC=C(NCCCCCCC(NO)=O)N=C1)NC2=CC=C(C(NC(C3=CC=CC(Cl)=C3)=O)=C2)Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 544.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Zhao J, Quan H, Xie C, Lou L. NL-103, a novel dual-targeted inhibitor of
histone deacetylases and hedgehog pathway, effectively overcomes vismodegib
resistance conferred by Smo mutations. Pharmacol Res Perspect. 2014
Jun;2(3):e00043. doi: 10.1002/prp2.43. Epub 2014 Apr 7. PubMed PMID: 25505589;
PubMed Central PMCID: PMC4186412.
2: Jurysta C, Louchami K, Malaisse WJ, Sener A. Uptake and efflux of
3-O-methyl-D-glucose in rat parotid cells. Biomed Rep. 2013 Jul;1(4):638-640.
Epub 2013 May 9. PubMed PMID: 24649000; PubMed Central PMCID: PMC3917550.
