Desoximetasone
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Hodoodo CAT#: H317590

CAS#: 382-67-2

Description: Desoximetasone is a medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation. Desoximetasone is a synthetic corticosteroid, a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents. Desoximetasone activates specific intracellular receptors, which bind to distinct sites on DNA to modify gene transcription. This results in an induction of the synthesis of anti-inflammatory proteins and suppression of the synthesis of inflammatory mediators. This leads to an overall reduction in chronic inflammation and autoimmune reactions. Desoximetasone is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. (Source: https://en.wikipedia.org/wiki/Desoximetasone).


Chemical Structure

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Desoximetasone
CAS# 382-67-2

Theoretical Analysis

Hodoodo Cat#: H317590
Name: Desoximetasone
CAS#: 382-67-2
Chemical Formula: C22H29FO4
Exact Mass: 376.20
Molecular Weight: 376.460
Elemental Analysis: C, 70.19; H, 7.76; F, 5.05; O, 17.00

Price and Availability

Size Price Availability Quantity
1g USD 250 Ready to ship
2g USD 400 Ready to ship
5g USD 650 Ready to ship
10g USD 950 Ready to ship
20g USD 1650 Ready to ship
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Synonym: A 41-304; A 41304; A-41-304; Desoximetasone; Desoximetasona; Desoximetasonum; Desoxymethasone; Flubason; baril; R 2113; Stiedex; Topicort; Topicort LP; Topisolon.

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: VWVSBHGCDBMOOT-IIEHVVJPSA-N

InChi Code: InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

SMILES Code: [C@@H]12[C@@]([C@@]3(C(=CC(=O)C=C3)CC2)C)([C@H](C[C@]2([C@H]1C[C@H]([C@@H]2C(=O)CO)C)C)O)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 376.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Keegan BR. Desoximetasone 0.25% Spray for the Relief of Scaling in Adults With Plaque Psoriasis. J Drugs Dermatol. 2015 Aug;14(8):835-40. PubMed PMID: 26267727.

2: Kircik L, Lebwohl MG, Del Rosso JQ, Bagel J, Stein Gold L, Weiss JS. Clinical study results of desoximetasone spray, 0.25% in moderate to severe plaque psoriasis. J Drugs Dermatol. 2013 Dec;12(12):1404-10. PubMed PMID: 24301242.

3: Stojković T, Binić I, Tiodorović J. [Evaluation of effect of local administration of desoximetasone and ditranol in psoriatic lesion byapplying 20 MHz ultrasound]. Med Pregl. 2012 Sep-Oct;65(9-10):368-72. Serbian. PubMed PMID: 23214328.

4: Borelli C, Gassmueller J, Fluhr JW, Nietsch KH, Schinzel S, Korting HC. Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay. Skin Pharmacol Physiol. 2008;21(3):181-7. doi: 10.1159/000131082. Epub 2008 Jun 3. PubMed PMID: 18523415.

5: Hebert AA, Koo J, Fowler J, Berman B, Rosenberg C, Levitt J. Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis. Cutis. 2006 Nov;78(5):357-63. PubMed PMID: 17186796.

6: Donovan JC, Dekoven JG. Cross-reactions to desoximetasone and mometasone furoate in a patient with multiple topical corticosteroid allergies. Dermatitis. 2006 Sep;17(3):147-51. PubMed PMID: 16956468.

7: Levitt J, Feldman T, Riss I, Leung OT. Compatibility of desoximetasone and tacrolimus. J Drugs Dermatol. 2003 Dec;2(6):640-2. PubMed PMID: 14711143.

8: Charuwichitratana S, Wattanakrai P, Tanrattanakorn S. Randomized double-blind placebo-controlled trial in the treatment of alopecia areata with 0.25% desoximetasone cream. Arch Dermatol. 2000 Oct;136(10):1276-7. PubMed PMID: 11030789.

9: Vladimirov S, Cudina O, Agbaba D, Jovanović M, Zivanov-Stakić D. Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. J Pharm Biomed Anal. 1996 Jun;14(8-10):947-50. PubMed PMID: 8817999.

10: Stierstorfer MB, Baughman RD. Photosensitivity to desoximetasone emollient cream. Arch Dermatol. 1988 Dec;124(12):1870-1. PubMed PMID: 3190264.