SMDC818909

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H407242

CAS#: 1147823-21-9

Description: SMDC818909 is a potent and selective p97 inhibitor. The IC50 value of SMDC818909 decreased with increasing ATP concentration (26.0 ± 0.9, 11.5 ± 0.9, and 4.9 ± 0.9 μM at 5, 20, and 100 μM ATP, respectively), indicating that it behaved primarily uncompetitively with the ATP substrate. SMDC818909 represents a novel uncompetitive inhibitor with excellent physical and pharmaceutical properties that can be used as a starting point for drug discovery efforts.

Chemical Structure

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SMDC818909
CAS# 1147823-21-9
Instruction

Theoretical Analysis

Hodoodo Cat#: H407242
Name: SMDC818909
CAS#: 1147823-21-9
Chemical Formula: C14H13N5O
Exact Mass: 267.11
Molecular Weight: 267.292
Elemental Analysis: C, 62.91; H, 4.90; N, 26.20; O, 5.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SMDC818909; SMDC 818909; SMDC-818909.

IUPAC/Chemical Name: 3-amino-N-(2-methyl-1H-indol-5-yl)pyrazine-2-carboxamide

InChi Key: PJTNJJWGQNSQDQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H13N5O/c1-8-6-9-7-10(2-3-11(9)18-8)19-14(20)12-13(15)17-5-4-16-12/h2-7,18H,1H3,(H2,15,17)(H,19,20)

SMILES Code: O=C(C1=NC=CN=C1N)NC2=CC3=C(NC(C)=C3)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 267.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Celeste Alverez†‡, Stacie L. Bulfer§, Ramappa Chakrasali∥, Michael. S. Chimenti§, Raymond J. Deshaies⊥, Neal Green#, Mark Kelly§, Matthew G. LaPorte‡, Taber S. Lewis‡, Mary Liang†‡, William J. Moore#, R. Jeffrey Neitz§, Vsevolod A. Peshkov‡, Michael A. Walters∥, Feng Zhang‡, Michelle R. Arkin*§, Peter Wipf*†‡, and Donna M. Huryn. ACS Med. Chem. Lett., Article ASAP; DOI: 10.1021/acsmedchemlett.5b00396. Publication Date (Web): December 22, 2015.