WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206527
CAS#: 38609-97-1 (free acid)
Description: Cridanimod, also known as XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.
Hodoodo Cat#: H206527
Name: Cridanimod
CAS#: 38609-97-1 (free acid)
Chemical Formula: C15H11NO3
Exact Mass: 253.07
Molecular Weight: 253.257
Elemental Analysis: C, 71.14; H, 4.38; N, 5.53; O, 18.95
Related CAS #: 58880-43-6 (sodium) 38609-97-1 (free acid),
Synonym: Cridanimod; XBIO101; XBIO-101; XBIO 101; Cycloferon; Cyclopheron;
IUPAC/Chemical Name: 2-(9-oxoacridin-10(9H)-yl)acetic acid
InChi Key: UOMKBIIXHQIERR-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
SMILES Code: C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 253.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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