SEW2871
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H522585

CAS#: 256414-75-2

Description: SEW2871 is a S1P1 agonist (sphingosine-1-phosphate type 1 receptor agonist). SEW2871 improves cognitive function in Alzheimer's disease model rats. SEW2871 prolongs heterotopic heart allograft survival in mice. SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. SEW2871 prolongs heterotopic heart allograft survival in mice.

Chemical Structure

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SEW2871
CAS# 256414-75-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H522585
Name: SEW2871
CAS#: 256414-75-2
Chemical Formula: C20H10F6N2OS
Exact Mass: 440.04
Molecular Weight: 440.363
Elemental Analysis: C, 54.55; H, 2.29; F, 25.89; N, 6.36; O, 3.63; S, 7.28

Price and Availability

Size Price Availability Quantity
10mg USD 210 2 Weeks
25mg USD 425 2 Weeks
50mg USD 725 2 Weeks
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Synonym: SEW2871; SEW2871; SEW2871.

IUPAC/Chemical Name: 5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

InChi Key: OYMNPJXKQVTQTR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H

SMILES Code: FC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zou L, Ke L, Wu C, Tong Z, Li W, Li N, Li J. SEW2871 Alleviates the Severity of Caerulein-Induced Acute Pancreatitis in Mice. Biol Pharm Bull. 2015;38(7):1012-9. doi: 10.1248/bpb.b15-00043. Epub 2015 May 2. PubMed PMID: 25948069.

2: Ni Q, Yuan B, Liu T, Lan F, Luo X, Lu X, Huang P, Dai L, Jin X, Yin H. Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. Int Immunopharmacol. 2015 May;26(1):37-42. doi: 10.1016/j.intimp.2015.03.004. Epub 2015 Mar 13. PubMed PMID: 25776899.

3: Dong J, Wang H, Zhao J, Sun J, Zhang T, Zuo L, Zhu W, Gong J, Li Y, Gu L, Li J. SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice. Immunol Res. 2015 Mar;61(3):303-11. doi: 10.1007/s12026-015-8625-5. PubMed PMID: 25588868.

4: Dong J, Wang H, Wu G, Zhao J, Zhang L, Zuo L, Zhu W, Gong J, Li Y, Gu L, Li J. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol. 2014 Jul;177(1):94-101. doi: 10.1111/cei.12304. PubMed PMID: 24611843; PubMed Central PMCID: PMC4089158.

5: Asle-Rousta M, Oryan S, Ahmadiani A, Rahnema M. Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer's disease model rats. EXCLI J. 2013 Jun 3;12:449-61. eCollection 2013. PubMed PMID: 26417237; PubMed Central PMCID: PMC4566907.

6: Rolin J, Sand KL, Knudsen E, Maghazachi AA. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010 Apr;59(4):575-86. doi: 10.1007/s00262-009-0775-7. Epub 2009 Oct 13. PubMed PMID: 19823820.

7: Tsukada YT, Sanna MG, Rosen H, Gottlieb RA. S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. J Cardiovasc Pharmacol. 2007 Dec;50(6):660-9. PubMed PMID: 18091583.

8: Lien YH, Yong KC, Cho C, Igarashi S, Lai LW. S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney Int. 2006 May;69(9):1601-8. PubMed PMID: 16572108.