WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522619
CAS#: 300837-31-4
Description: XCT0135908 is a RXR agonist. XCT0135908 showed selectivity for RXR−Nurr1 over a broad range of other RXR dimerization partners but with rather low potency. XCT0135908 yielded promising results in a rat neuron PD model. Note: Sci-Finder registered this compound as XCT 0315908.
Hodoodo Cat#: H522619
Name: XCT0135908
CAS#: 300837-31-4
Chemical Formula: C21H19N3O2
Exact Mass: 345.15
Molecular Weight: 345.402
Elemental Analysis: C, 73.03; H, 5.54; N, 12.17; O, 9.26
Synonym: XCT0135908; XCT-0135908; XCT 0135908.
IUPAC/Chemical Name: 4-((5-allyl-6-methyl-2-phenylpyrimidin-4-yl)amino)benzoic acid
InChi Key: SQYRBODOBCAROZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N3O2/c1-3-7-18-14(2)22-19(15-8-5-4-6-9-15)24-20(18)23-17-12-10-16(11-13-17)21(25)26/h3-6,8-13H,1,7H2,2H3,(H,25,26)(H,22,23,24)
SMILES Code: O=C(O)C1=CC=C(NC2=NC(C3=CC=CC=C3)=NC(C)=C2CC=C)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 345.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Preparation of 4-amino substituted condensed pyrimidine compounds as selective PDE4 inhibitors useful in treatment of diseases
By Konetzki, Ingo; Jakob, Florian; Craan, Tobias; Hesslinger, Christian
From PCT Int. Appl. (2014), WO 2014117947 A1 20140807. | Language: English, Database: CAPLUS
2. Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
By Gurney, Mark E.; Atkins, Collen M.; Adaikkalasamy, David J.; Dietrich, W. Dalton
From U.S. Pat. Appl. Publ. (2014), US 20140121221 A1 20140501. | Language: English, Database: CAPLUS
3. Treatment of neurodegenerative diseases using retinoid X receptor (RXR)-selective agonists
By Burstein, Ethan S.; Olsson, Roger; McFarland, Krista
From PCT Int. Appl. (2013), WO 2013020966 A1 20130214. | Language: English, Database: CAPLUS
4. Treatment of neurodegenerative diseases using retinoid X receptor (RXR)-selective agonists
By Burstein, Ethan S.; Olsson, Roger; McFarland, Krista
From Eur. Pat. Appl. (2013), EP 2556827 A1 20130213. | Language: English, Database: CAPLUS
5. Discovery of selective PDE4B inhibitors
By Naganuma, Kenji; Omura, Akifumi; Maekawara, Naomi; Saitoh, Masahiro; Ohkawa, Naoto; Kubota, Takashi; Nagumo, Hiromitsu; Kodama, Toshiyuki; Takemura, Masayoshi; Ohtsuka, Yuji; et al
From Bioorganic & Medicinal Chemistry Letters (2009), 19(12), 3174-3176. | Language: English, Database: CAPLUS
6. Electrospray Mass Spectrometry for the Direct Accurate Mass Measurement of Ligands in Complex With the Retinoid X Receptor α Ligand Binding
By Lengqvist, Johan; Alvelius, Gunvor; Joernvall, Hans; Sjoevall, Jan; Perlmann, Thomas; Griffiths, William J.
From Journal of the American Society for Mass Spectrometry (2005), 16(10), 1631-1640. | Language: English, Database: CAPLUS
7. Substituted pyrimidine compositions and methods using them for the treatment of NGFI-B-related diseases
By Martin, Richard; Mohan, Raju; Ordentlich, Peter
From PCT Int. Appl. (2005), WO 2005047268 A2 20050526. | Language: English, Database: CAPLUS
