WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H317892
CAS#: 2709-56-0
Description: Flupentixol is a typical antipsychotic drug of the thioxanthene class. Flupentixol's main use is as a long-acting injection given once in every two or three weeks to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness. Flupentixol is also used in low doses as an antidepressant. There is tentative evidence that it reduces the rate of deliberate self-harm, among those who self harm repeatedly.
Hodoodo Cat#: H317892
Name: Flupenthixol
CAS#: 2709-56-0
Chemical Formula: C23H25F3N2OS
Exact Mass: 434.16
Molecular Weight: 434.518
Elemental Analysis: C, 63.58; H, 5.80; F, 13.12; N, 6.45; O, 3.68; S, 7.38
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Synonym: Flupenthixol, Flupenthixol, Depixol, Fluanxol, Emergil, Siplaril
IUPAC/Chemical Name: 2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
InChi Key: NJMYODHXAKYRHW-DVZOWYKESA-N
InChi Code: InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5-
SMILES Code: FC(C1=CC(/C2=C\CCN3CCN(CCO)CC3)=C(SC4=C2C=CC=C4)C=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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In vitro activity: | |
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The following data is based on the product molecular weight 434.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tardy M, Dold M, Engel RR, Leucht S. Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev. 2014 Sep 1;9:CD009227. doi: 10.1002/14651858.CD009227.pub2. Review. PubMed PMID: 25177834.
2: Mahapatra J, Quraishi SN, David A, Sampson S, Adams CE. Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders. Cochrane Database Syst Rev. 2014 Jun 10;6:CD001470. doi: 10.1002/14651858.CD001470.pub2. Review. PubMed PMID: 24915451.
3: Shen X, Xia J, Adams CE. Flupenthixol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2012 Nov 14;11:CD009777. doi: 10.1002/14651858.CD009777.pub2. Review. PubMed PMID: 23152280.
4: Soyka M, De Vry J. Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence. Eur Neuropsychopharmacol. 2000 Sep;10(5):325-32. Review. PubMed PMID0974602.
5: Kühn KU, Meyer K, Maier W. [Flupenthixol--a partial atypical neuroleptic?]. Fortschr Neurol Psychiatr. 2000 Apr;68 Suppl 1:S38-41. Review. German. PubMed PMID: 10907612.
6: Quraishi S, David A. Depot flupenthixol decanoate for schizophrenia or other similar psychotic disorders. Cochrane Database Syst Rev. 2000;(2):CD001470. Review. Update in: Cochrane Database Syst Rev. 2014;6:CD001470. PubMed PMID: 10796442.
7: Gruber AJ, Cole JO. Antidepressant effects of flupenthixol. Pharmacotherapy. 1991;11(6):450-9. Review. PubMed PMID: 1771144.