WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H318184
CAS#: 58-27-5
Description: Menadione is a dietary nutrient essential for the normal biosynthesis of factors that are required for blood clotting. Menadione is a synthetic chemical compound sometimes used as a nutritional supplement because of its vitamin K activity. It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position. It has also been shown to inhibit cell growth. Vitamin K3 is a synthetic form of vitamin K that acts as a precursor to vitamin K2. It is capable of both redox cycling and arylating nucleophilic substrates by Michael addition and has been used as a model bifunctional quinone to study cellular stress induction.
Hodoodo Cat#: H318184
Name: Menadione
CAS#: 58-27-5
Chemical Formula: C11H8O2
Exact Mass: 172.05
Molecular Weight: 172.183
Elemental Analysis: C, 76.73; H, 4.68; O, 18.58
Synonym: Menadione; Vitamin K3; 2-Methyl-1,4-naphthoquinone; Menaphthone; Thyloquinone; Vitamin K3 sodium bisulfite; Vicasol; Vikasol;Menadione bisulfite;
IUPAC/Chemical Name: 2-methylnaphthalene-1,4-dione
InChi Key: MJVAVZPDRWSRRC-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
SMILES Code: CC1=CC(=O)C2=CC=CC=C2C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 172.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
1: Halilovic A, Schmedt T, Benischke AS, Hamill CE, Chen Y, Santos JH, Jurkunas UV. Menadione-induced DNA damage leads to mitochondrial dysfunction and fragmentation during rosette formation in Fuchs Endothelial Corneal Dystrophy. Antioxid Redox Signal. 2016 Mar 2. [Epub ahead of print] PubMed PMID: 26935406.
2: Tofolean IT, Ganea C, Ionescu D, Filippi A, Garaiman A, Goicea A, Gaman MA, Dimancea A, Baran I. Cellular determinants involving mitochondrial dysfunction, oxidative stress and apoptosis correlate with the synergic cytotoxicity of epigallocatechin-3-gallate and menadione in human leukemia Jurkat T cells. Pharmacol Res. 2016 Jan;103:300-17. doi: 10.1016/j.phrs.2015.12.013. Epub 2015 Dec 11. PubMed PMID: 26687095.
3: Arslan M, Sevgiler Y, Buyukleyla M, Yardimci M, Yilmaz M, Rencuzogullari E. Sex-related effects of imidacloprid modulated by piperonyl butoxide and menadione in rats. Part II: genotoxic and cytotoxic potential. Drug Chem Toxicol. 2016 Jan;39(1):81-6. doi: 10.3109/01480545.2015.1029049. Epub 2015 Sep 25. PubMed PMID: 25826181.
