WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522682
CAS#: 1599432-08-2
Description: NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). NIBR-189 blocks migration of a monocyte cell line called U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.
Hodoodo Cat#: H522682
Name: NIBR-189
CAS#: 1599432-08-2
Chemical Formula: C21H21BrN2O3
Exact Mass: 428.07
Molecular Weight: 429.314
Elemental Analysis: C, 58.75; H, 4.93; Br, 18.61; N, 6.53; O, 11.18
Synonym: NIBR-189; NIBR 189; NIBR189.
IUPAC/Chemical Name: (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
InChi Key: OFHXXBRBGWUOHR-NYYWCZLTSA-N
InChi Code: InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+
SMILES Code: O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 429.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA,
Marsilje TH, Seuwen K, Nguyen DG, Sailer AW. Identification and characterization
of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2)
receptor. J Med Chem. 2014 Apr 24;57(8):3358-68. doi: 10.1021/jm4019355. Epub
2014 Apr 15. PubMed PMID: 24678947.
