WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H318490
CAS#: 51446-62-9
Description: Phosphatidylserine is an important phospholipid membrane component which plays a key role in cell cycle signaling, specifically in relationship to apoptosis.Phosphatidylserine is a fatty molecule, a phospholipid, which contains both amino and fatty acids. The fatty acids include omega-3 and omega-6 fatty acid molecules. Phosphatidylserine is widely used as nutritional supplement.
Hodoodo Cat#: H318490
Name: Phosphatidylserine
CAS#: 51446-62-9
Chemical Formula: C42H82NO10P
Exact Mass: 791.57
Molecular Weight: 792.070
Elemental Analysis: C, 63.69; H, 10.43; N, 1.77; O, 20.20; P, 3.91
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Phosphatidylserine; Distearoyl phosphatidylserine; Phosphatidylserine(36:0); Dioctadecanoylphosphatidylserine; C42H82NO10P; CHEBI:84519; HMDB12378;
IUPAC/Chemical Name: (2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid
InChi Key: TZCPCKNHXULUIY-UHFFFAOYSA-N
InChi Code: InChI=1S/C42H82NO10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49)
SMILES Code: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 792.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Wesseling MC, Wagner-Britz L, Huppert H, Hanf B, Hertz L, Nguyen DB, Bernhardt
I. Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age.
Cell Physiol Biochem. 2016 Mar 24;38(4):1376-1390. [Epub ahead of print] PubMed
PMID: 27007671.
2: Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, Angelot-Delettre F,
Ceroi A, Grauffel C, Benhamou M, Reuter N, Saas P, Frachet P, Boulanger CM,
Witko-Sarsat V. Proteinase 3 is a phosphatidylserine binding protein which
affects the production and function of microvesicles. J Biol Chem. 2016 Mar 9.
pii: jbc.M115.698639. [Epub ahead of print] PubMed PMID: 26961880.
3: Majumder R, Koklic T, Rezaie AR, Lentz BR. Correction to
Phosphatidylserine-Induced Factor Xa Dimerization and Binding to Factor Va Are
Competing Processes in Solution. Biochemistry. 2016 Mar 15;55(10):1554. doi:
10.1021/acs.biochem.6b00112. Epub 2016 Mar 4. PubMed PMID: 26943353.
4: Mandaliti W, Nepravishta R, Sinibaldi Vallebona P, Pica F, Garaci E, Paci M.
Thymosin α1 Interacts with Exposed Phosphatidylserine in Membrane Models and in
Cells and Uses Serum Albumin as a Carrier. Biochemistry. 2016 Mar
15;55(10):1462-72. doi: 10.1021/acs.biochem.5b01345. Epub 2016 Mar 3. PubMed
PMID: 26909491.
5: Qadri SM, Donkor DA, Bhakta V, Eltringham-Smith LJ, Dwivedi DJ, Moore JC,
Pepler L, Ivetic N, Nazi I, Fox-Robichaud AE, Liaw PC, Sheffield WP.
Phosphatidylserine externalization and procoagulant activation of erythrocytes
induced by Pseudomonas aeruginosa virulence factor pyocyanin. J Cell Mol Med.
2016 Apr;20(4):710-20. doi: 10.1111/jcmm.12778. Epub 2016 Jan 19. PubMed PMID:
26781477.
6: Officioso A, Alzoubi K, Lang F, Manna C. Hydroxytyrosol inhibits
phosphatidylserine exposure and suicidal death induced by mercury in human
erythrocytes: Possible involvement of the glutathione pathway. Food Chem Toxicol.
2016 Mar;89:47-53. doi: 10.1016/j.fct.2016.01.003. Epub 2016 Jan 13. PubMed PMID:
26774912.
7: Donyo M, Hollander D, Abramovitch Z, Naftelberg S, Ast G. Phosphatidylserine
enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway. Hum
Mol Genet. 2016 Apr 1;25(7):1307-17. doi: 10.1093/hmg/ddw011. Epub 2016 Jan 13.
PubMed PMID: 26769675.
8: Choi JY, Kumar V, Pachikara N, Garg A, Lawres L, Toh JY, Voelker DR, Ben
Mamoun C. Characterization of Plasmodium phosphatidylserine decarboxylase
expressed in yeast and application for inhibitor screening. Mol Microbiol. 2016
Mar;99(6):999-1014. doi: 10.1111/mmi.13280. Epub 2015 Dec 22. PubMed PMID:
26585333.
9: Zhang Y, Meng H, Ma R, He Z, Wu X, Cao M, Yao Z, Zhao L, Li T, Deng R, Dong Z,
Tian Y, Bi Y, Kou J, Thatte HS, Zhou J, Shi J. CIRCULATING MICROPARTICLES, BLOOD
CELLS, AND ENDOTHELIUM INDUCE PROCOAGULANT ACTIVITY IN SEPSIS THROUGH
PHOSPHATIDYLSERINE EXPOSURE. Shock. 2016 Mar;45(3):299-307. doi:
10.1097/SHK.0000000000000509. PubMed PMID: 26513704.
10: Varela Chavez C, Haustant GM, Baron B, England P, Chenal A, Pauillac S,
Blondel A, Popoff MR. The Tip of the Four N-Terminal α-Helices of Clostridium
sordellii Lethal Toxin Contains the Interaction Site with Membrane
Phosphatidylserine Facilitating Small GTPases Glucosylation. Toxins (Basel). 2016
Mar 25;8(4). pii: E90. PubMed PMID: 27023605.
11: Zhao L, Bi Y, Kou J, Shi J, Piao D. Phosphatidylserine exposing-platelets and
microparticles promote procoagulant activity in colon cancer patients. J Exp Clin
Cancer Res. 2016 Mar 25;35(1):54. doi: 10.1186/s13046-016-0328-9. PubMed PMID:
27015840; PubMed Central PMCID: PMC4807543.
12: Bevers EM, Williamson PL. Getting to the Outer Leaflet: Physiology of
Phosphatidylserine Exposure at the Plasma Membrane. Physiol Rev. 2016
Apr;96(2):605-45. doi: 10.1152/physrev.00020.2015. Review. PubMed PMID: 26936867.
13: Shiu WL, Huang KR, Hung JC, Wu JL, Hong JR. Knockdown of zebrafish YY1a can
downregulate the phosphatidylserine (PS) receptor expression, leading to induce
the abnormal brain and heart development. J Biomed Sci. 2016 Feb 29;23(1):31.
doi: 10.1186/s12929-016-0248-1. PubMed PMID: 26924789; PubMed Central PMCID:
PMC4770675.
14: Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski
M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ,
Schett G, Herrmann M. Phosphatidylserine is a global immunosuppressive signal in
efferocytosis, infectious disease, and cancer. Cell Death Differ. 2016 Feb 26.
doi: 10.1038/cdd.2016.11. [Epub ahead of print] Review. PubMed PMID: 26915293.
15: Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD,
Marshall CA, Perrie Y, O'Donnell VB, Harwood JL, Sabroe I, Parker LC. Human
rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine
containing liposomes. Mucosal Immunol. 2016 Feb 24. doi: 10.1038/mi.2015.137.
[Epub ahead of print] PubMed PMID: 26906404.
16: Fujieda Y, Amengual O, Matsumoto M, Kuroki K, Takahashi H, Kono M, Kurita T,
Otomo K, Kato M, Oku K, Bohgaki T, Horita T, Yasuda S, Maenaka K, Hatakeyama S,
Nakayama KI, Atsumi T. Ribophorin II is involved in the tissue factor expression
mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology (Oxford). 2016 Feb 19. pii: kew005. [Epub ahead of print] PubMed
PMID: 26895716.
17: Fernandez-Arias C, Rivera-Correa J, Gallego-Delgado J, Rudlaff R, Fernandez
C, Roussel C, Götz A, Gonzalez S, Mohanty A, Mohanty S, Wassmer S, Buffet P,
Ndour PA, Rodriguez A. Anti-Self Phosphatidylserine Antibodies Recognize
Uninfected Erythrocytes Promoting Malarial Anemia. Cell Host Microbe. 2016 Feb
10;19(2):194-203. doi: 10.1016/j.chom.2016.01.009. PubMed PMID: 26867178.
18: Cheng X, Li L, Thorpe PE, Yopp AC, Brekken RA, Huang X. Antibody-Mediated
Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in
Hepatocellular Carcinomas Xenografts. Ann Surg Oncol. 2016 Feb 4. [Epub ahead of
print] PubMed PMID: 26847681.
19: Li YH, Yu SL, Gan XG, Pan SH, Teng YQ, An RH. Externalization of
phosphatidylserine via multidrug resistance 1 (MDR1)/P-glycoprotein in
oxalate-treated renal epithelial cells: implications for calcium oxalate
urolithiasis. Int Urol Nephrol. 2016 Feb;48(2):175-81. doi:
10.1007/s11255-015-1155-1. Epub 2015 Nov 11. PubMed PMID: 26560472.
20: Nagata S, Suzuki J, Segawa K, Fujii T. Exposure of phosphatidylserine on the
cell surface. Cell Death Differ. 2016 Feb 19. doi: 10.1038/cdd.2016.7. [Epub
ahead of print] Review. PubMed PMID: 26891692.
